• Login
    View Item 
    •   Home
    • Research
    • Articles
    • View Item
    •   Home
    • Research
    • Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of KAUSTCommunitiesIssue DateSubmit DateThis CollectionIssue DateSubmit Date

    My Account

    Login

    Quick Links

    Open Access PolicyORCID LibguidePlumX LibguideSubmit an Item

    Statistics

    Display statistics

    Tailoring super-hydrophobic properties of electrochemical biosensor for early cancer detection

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    tailoring_superhydrophobic_properties_of_electrochemical_biosensor_for_early_cancer_detection.pdf
    Size:
    368.6Kb
    Format:
    PDF
    Description:
    Main article
    Download
    Type
    Article
    Authors
    Malara, Natalia
    Gentile, Francesco
    Ferrara, Lorenzo cc
    Villani, Marco
    Iannotta, Salvatore
    Zappettini, Andrea
    Di Fabrizio, Enzo M. cc
    Trunzo, Valentina
    Mollace, Vincenzo
    Coppedé, Nicola
    KAUST Department
    Material Science and Engineering Program
    Physical Science and Engineering (PSE) Division
    Date
    2016-08-05
    Online Publication Date
    2016-08-05
    Print Publication Date
    2016
    Permanent link to this record
    http://hdl.handle.net/10754/625234
    
    Metadata
    Show full item record
    Abstract
    In this paper, we demonstrate an organic electrochemical transistor (OECT) based on the conductive polymer PEDOT:PSS for the analysis of the cell culture medium upon interaction with circulating cells isolated form peripheral blood sampling of health, sub-clinical and cancer patients. The device comprises arrays of super-hydrophobic micro-pillars in which a finite number of pillars incorporates nano-electrodes for site specific measurements of a solution. Due to its nano-scale architecture, the device realizes time and space resolved measurement of biological solution. Tumor metabolism could produce reactive species able to determine a different electronic behavior of correspondent microenviroment. On this basis, the device here presented the changes in the ESR signals was used to identify electronic changes occurring in the analysis of different type of microenvironment. Our results demonstrate that the device is able to register significative difference to differentiate healthy individuals form cancer patients, through an easy blood sampling. In conclusion, these preliminary data are suggestive of a novel test potentially useful to early identification of subjects at risk to development cancer disease.
    Citation
    Malara N, Gentile F, Ferrara L, Villani M, Iannotta S, et al. (2016) Tailoring super-hydrophobic properties of electrochemical biosensor for early cancer detection. MRS Advances 1: 3545–3552. Available: http://dx.doi.org/10.1557/adv.2016.543.
    Sponsors
    This work has been partially funded from the Italian Minister of Health (Project n. GR-2010-2320665) and by the project Interregional Research Centre for Food Safety & health (IRC_FSH) (cod. PON a3-00359), granted to the Department of Health Science, University Magna Graecia. NC acknowledges Nicola Zambelli and Giacomo Benassi for technical support. NM acknowledges Prof. Bruno Silvestrini for scientific support. The authors would like to thank the patients and all health professionals involved at the University
    Publisher
    Cambridge University Press (CUP)
    Journal
    MRS Advances
    DOI
    10.1557/adv.2016.543
    Additional Links
    https://www.cambridge.org/core/journals/mrs-advances/article/tailoring-superhydrophobic-properties-of-electrochemical-biosensor-for-early-cancer-detection/E48FB47683DC576A9F444627ABB1C86A
    ae974a485f413a2113503eed53cd6c53
    10.1557/adv.2016.543
    Scopus Count
    Collections
    Articles; Physical Science and Engineering (PSE) Division; Material Science and Engineering Program

    entitlement

     
    DSpace software copyright © 2002-2021  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service hosted by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items. For anonymous users the allowed maximum amount is 50 search results.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.