Tailoring super-hydrophobic properties of electrochemical biosensor for early cancer detection
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ArticleAuthors
Malara, NataliaGentile, Francesco
Ferrara, Lorenzo

Villani, Marco
Iannotta, Salvatore
Zappettini, Andrea
Di Fabrizio, Enzo M.

Trunzo, Valentina
Mollace, Vincenzo
Coppedé, Nicola
KAUST Department
Material Science and Engineering ProgramPhysical Science and Engineering (PSE) Division
Date
2016-08-05Online Publication Date
2016-08-05Print Publication Date
2016Permanent link to this record
http://hdl.handle.net/10754/625234
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In this paper, we demonstrate an organic electrochemical transistor (OECT) based on the conductive polymer PEDOT:PSS for the analysis of the cell culture medium upon interaction with circulating cells isolated form peripheral blood sampling of health, sub-clinical and cancer patients. The device comprises arrays of super-hydrophobic micro-pillars in which a finite number of pillars incorporates nano-electrodes for site specific measurements of a solution. Due to its nano-scale architecture, the device realizes time and space resolved measurement of biological solution. Tumor metabolism could produce reactive species able to determine a different electronic behavior of correspondent microenviroment. On this basis, the device here presented the changes in the ESR signals was used to identify electronic changes occurring in the analysis of different type of microenvironment. Our results demonstrate that the device is able to register significative difference to differentiate healthy individuals form cancer patients, through an easy blood sampling. In conclusion, these preliminary data are suggestive of a novel test potentially useful to early identification of subjects at risk to development cancer disease.Citation
Malara N, Gentile F, Ferrara L, Villani M, Iannotta S, et al. (2016) Tailoring super-hydrophobic properties of electrochemical biosensor for early cancer detection. MRS Advances 1: 3545–3552. Available: http://dx.doi.org/10.1557/adv.2016.543.Sponsors
This work has been partially funded from the Italian Minister of Health (Project n. GR-2010-2320665) and by the project Interregional Research Centre for Food Safety & health (IRC_FSH) (cod. PON a3-00359), granted to the Department of Health Science, University Magna Graecia. NC acknowledges Nicola Zambelli and Giacomo Benassi for technical support. NM acknowledges Prof. Bruno Silvestrini for scientific support. The authors would like to thank the patients and all health professionals involved at the UniversityPublisher
Cambridge University Press (CUP)Journal
MRS Advancesae974a485f413a2113503eed53cd6c53
10.1557/adv.2016.543