MAPK-triggered chromatin reprogramming by histone deacetylase in plant innate immunity

Abstract
Microbial-associated molecular patterns activate several MAP kinases, which are major regulators of the innate immune response in Arabidopsis thaliana that induce large-scale changes in gene expression. Here, we determine whether microbial-associated molecular pattern-triggered gene expression involves modifications at the chromatin level.Histone acetylation and deacetylation are major regulators of microbial-associated molecular pattern-triggered gene expression and implicate the histone deacetylase HD2B in the reprogramming of defence gene expression and innate immunity. The MAP kinase MPK3 directly interacts with and phosphorylates HD2B, thereby regulating the intra-nuclear compartmentalization and function of the histone deacetylase.By studying a number of gene loci that undergo microbial-associated molecular pattern-dependent activation or repression, our data reveal a mechanistic model for how protein kinase signaling directly impacts chromatin reprogramming in plant defense.

Citation
Latrasse D, Jégu T, Li H, de Zelicourt A, Raynaud C, et al. (2017) MAPK-triggered chromatin reprogramming by histone deacetylase in plant innate immunity. Genome Biology 18. Available: http://dx.doi.org/10.1186/s13059-017-1261-8.

Acknowledgements
Funding for the project was provided to HH and MB by a grant of the French National Agency of Research (LabEx Saclay Plant Sciences-SPS ANR-10-LABX-0040-SPS) as well as by grant CRG4 of the King Abdullah University of Science and Technology. Moreover, OS was supported by the Czech Science Foundation GA ČR grant no. GA16-22044S. No ethics approval was required for this project.

Publisher
Springer Nature

Journal
Genome Biology

DOI
10.1186/s13059-017-1261-8

PubMed ID
28683804

Additional Links
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1261-8

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