Nickel-Catalyzed C–O Bond-Cleaving Alkylation of Esters: Direct Replacement of the Ester Moiety by Functionalized Alkyl Chains
Type
ArticleKAUST Department
Chemical Science ProgramKAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Date
2017-06-07Online Publication Date
2017-06-07Print Publication Date
2017-07-07Permanent link to this record
http://hdl.handle.net/10754/625106
Metadata
Show full item recordAbstract
Two efficient protocols for the nickel-catalyzed aryl–alkyl cross-coupling reactions using esters as coupling components have been established. The methods enable the selective oxidative addition of nickel to acyl C–O and aryl C–O bonds and allow the aryl–alkyl cross-coupling via decarbonylative bond cleavage or through cleavage of a C–O bond with high efficiency and good functional group compatibility. The protocols allow the streamlined, unconventional utilization of widespread ester groups and their precursors, carboxylic acids and phenols, in synthetic organic chemistry.Citation
Liu X, Jia J, Rueping M (2017) Nickel-Catalyzed C–O Bond-Cleaving Alkylation of Esters: Direct Replacement of the Ester Moiety by Functionalized Alkyl Chains. ACS Catalysis 7: 4491–4496. Available: http://dx.doi.org/10.1021/acscatal.7b00941.Sponsors
X.L. was supported by the China Scholarship Council.Publisher
American Chemical Society (ACS)Journal
ACS CatalysisAdditional Links
http://pubs.acs.org/doi/full/10.1021/acscatal.7b00941ae974a485f413a2113503eed53cd6c53
10.1021/acscatal.7b00941