Type
ArticleAuthors
Fenzl, ChristophNayak, Pranati
Hirsch, Thomas
Wolfbeis, Otto S.
Alshareef, Husam N.

Baeumner, Antje J.
KAUST Department
Functional Nanomaterials and Devices Research GroupMaterial Science and Engineering Program
Physical Science and Engineering (PSE) Division
Date
2017-05Online Publication Date
2017-05Print Publication Date
2017-05-26Permanent link to this record
http://hdl.handle.net/10754/625103
Metadata
Show full item recordAbstract
Graphene as a transducer material has produced some of the best performing sensing approaches to date opening the door toward integrated miniaturized all-carbon point-of-care devices. Addressing this opportunity, laser-scribed graphene(LSG) electrodes are demonstrated here as highly sensitive and reliable biosensor transducers in blood serum analysis. These flexible electrodes with large electrochemical surface areas were fabricated using a direct-write laser process on polyimide foils. A universal immobilization approach is established by anchoring 1-pyrenebutyric acid to the graphene and subsequently covalently attaching an aptamer against the coagulation factor thrombin as an exemplary bioreceptor to the carboxyl groups. The resulting biosensor displays extremely low detection limits of 1 pM in buffer and 5 pM in the complex matrix of serum.Citation
Fenzl C, Nayak P, Hirsch T, Wolfbeis OS, Alshareef HN, et al. (2017) Laser-Scribed Graphene Electrodes for Aptamer-Based Biosensing. ACS Sensors 2: 616–620. Available: http://dx.doi.org/10.1021/acssensors.7b00066.Sponsors
Research reported in this publication was supported in part by funding from King Abdullah University of Science and Technology (KAUST).Publisher
American Chemical Society (ACS)Journal
ACS SensorsAdditional Links
http://pubs.acs.org/doi/full/10.1021/acssensors.7b00066ae974a485f413a2113503eed53cd6c53
10.1021/acssensors.7b00066