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    Laser-Scribed Graphene Electrodes for Aptamer-Based Biosensing

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    Type
    Article
    Authors
    Fenzl, Christoph
    Nayak, Pranati
    Hirsch, Thomas
    Wolfbeis, Otto S.
    Alshareef, Husam N. cc
    Baeumner, Antje J.
    KAUST Department
    Functional Nanomaterials and Devices Research Group
    Material Science and Engineering Program
    Physical Science and Engineering (PSE) Division
    Date
    2017-05
    Online Publication Date
    2017-05
    Print Publication Date
    2017-05-26
    Permanent link to this record
    http://hdl.handle.net/10754/625103
    
    Metadata
    Show full item record
    Abstract
    Graphene as a transducer material has produced some of the best performing sensing approaches to date opening the door toward integrated miniaturized all-carbon point-of-care devices. Addressing this opportunity, laser-scribed graphene(LSG) electrodes are demonstrated here as highly sensitive and reliable biosensor transducers in blood serum analysis. These flexible electrodes with large electrochemical surface areas were fabricated using a direct-write laser process on polyimide foils. A universal immobilization approach is established by anchoring 1-pyrenebutyric acid to the graphene and subsequently covalently attaching an aptamer against the coagulation factor thrombin as an exemplary bioreceptor to the carboxyl groups. The resulting biosensor displays extremely low detection limits of 1 pM in buffer and 5 pM in the complex matrix of serum.
    Citation
    Fenzl C, Nayak P, Hirsch T, Wolfbeis OS, Alshareef HN, et al. (2017) Laser-Scribed Graphene Electrodes for Aptamer-Based Biosensing. ACS Sensors 2: 616–620. Available: http://dx.doi.org/10.1021/acssensors.7b00066.
    Sponsors
    Research reported in this publication was supported in part by funding from King Abdullah University of Science and Technology (KAUST).
    Publisher
    American Chemical Society (ACS)
    Journal
    ACS Sensors
    DOI
    10.1021/acssensors.7b00066
    Additional Links
    http://pubs.acs.org/doi/full/10.1021/acssensors.7b00066
    ae974a485f413a2113503eed53cd6c53
    10.1021/acssensors.7b00066
    Scopus Count
    Collections
    Articles; Physical Science and Engineering (PSE) Division; Material Science and Engineering Program

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