Amide to Alkyne Interconversion via a Nickel/Copper-Catalyzed Deamidative Cross-Coupling of Aryl and Alkenyl Amides
KAUST DepartmentChemical Science Program
KAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Permanent link to this recordhttp://hdl.handle.net/10754/625096
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AbstractA nickel-catalyzed deamidative cross-coupling reaction of amides with terminal alkynes as coupling partners was disclosed. This newly developed methodology allows the direct interconversion of amides to alkynes and enables a facile route for C(sp2)-C(sp) bond formation in a straightforward and mild fashion.
CitationSrimontree W, Chatupheeraphat A, Liao H-H, Rueping M (2017) Amide to Alkyne Interconversion via a Nickel/Copper-Catalyzed Deamidative Cross-Coupling of Aryl and Alkenyl Amides. Organic Letters 19: 3091–3094. Available: http://dx.doi.org/10.1021/acs.orglett.7b01194.
SponsorsH.-H.L. acknowledges the DAAD for a doctoral fellowship.
PublisherAmerican Chemical Society (ACS)
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