Amide to Alkyne Interconversion via a Nickel/Copper-Catalyzed Deamidative Cross-Coupling of Aryl and Alkenyl Amides

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Type
Article
Authors
Srimontree, Watchara
Chatupheeraphat, Adisak
Liao, Hsuan-Hung
Rueping, Magnus cc
KAUST Department
Physical Sciences and Engineering (PSE) Division
Chemical Science Program
KAUST Catalysis Center (KCC)
Date
2017-06-05

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Abstract
A nickel-catalyzed deamidative cross-coupling reaction of amides with terminal alkynes as coupling partners was disclosed. This newly developed methodology allows the direct interconversion of amides to alkynes and enables a facile route for C(sp2)-C(sp) bond formation in a straightforward and mild fashion.
Citation
Srimontree W, Chatupheeraphat A, Liao H-H, Rueping M (2017) Amide to Alkyne Interconversion via a Nickel/Copper-Catalyzed Deamidative Cross-Coupling of Aryl and Alkenyl Amides. Organic Letters 19: 3091–3094. Available: http://dx.doi.org/10.1021/acs.orglett.7b01194.
Sponsors
H.-H.L. acknowledges the DAAD for a doctoral fellowship.
Publisher
American Chemical Society (ACS)
Journal
Organic Letters
ISSN
1523-7060
1523-7052
DOI
10.1021/acs.orglett.7b01194
PubMed ID
28581761
Handle URI
http://hdl.handle.net/10754/625096
Additional Links
http://pubs.acs.org/doi/full/10.1021/acs.orglett.7b01194
Collections
Articles; Physical Sciences and Engineering (PSE) Division; Chemical Science Program; KAUST Catalysis Center (KCC)