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    Thermoresponsive pegylated bubble liposome nanovectors for efficient siRNA delivery via endosomal escape

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    Type
    Article
    Authors
    Alamoudi, Kholod cc
    Martins, Patricia
    Croissant, Jonas G.
    Patil, Sachin cc
    Omar, Haneen cc
    Khashab, Niveen M. cc
    KAUST Department
    Advanced Membranes and Porous Materials Research Center
    Bioscience Program
    Chemical Science Program
    Physical Science and Engineering (PSE) Division
    Smart Hybrid Materials (SHMs) lab
    Water Desalination and Reuse Research Center (WDRC)
    Date
    2017-05-19
    Online Publication Date
    2017-05-19
    Print Publication Date
    2017-06
    Permanent link to this record
    http://hdl.handle.net/10754/625030
    
    Metadata
    Show full item record
    Abstract
    Improving the delivery of siRNA into cancer cells via bubble liposomes. Designing a thermoresponsive pegylated liposome through the introduction of ammonium bicarbonate salt into liposomes so as to control their endosomal escape for gene therapy.A sub-200 nm nanovector was fully characterized and examined for cellular uptake, cytotoxicity, endosomal escape and gene silencing.The siRNA-liposomes were internalized into cancer cells within 5 min and then released siRNAs in the cytosol prior to lysosomal degradation upon external temperature elevation. This was confirmed by confocal bioimaging and gene silencing reaching up to 90% and further demonstrated by the protein inhibition of both target genes.The thermoresponsiveness of ammonium bicarbonate containing liposomes enabled the rapid endosomal escape of the particles and resulted in an efficient gene silencing.
    Citation
    Alamoudi K, Martins P, Croissant JG, Patil S, Omar H, et al. (2017) Thermoresponsive pegylated bubble liposome nanovectors for efficient siRNA delivery via endosomal escape. Nanomedicine. Available: http://dx.doi.org/10.2217/nnm-2017-0021.
    Sponsors
    We gratefully acknowledge support from King Abdullah University of Science and Technology (KAUST). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
    Publisher
    Future Medicine Ltd
    Journal
    Nanomedicine
    DOI
    10.2217/nnm-2017-0021
    PubMed ID
    28524721
    Additional Links
    http://www.futuremedicine.com/doi/10.2217/nnm-2017-0021
    ae974a485f413a2113503eed53cd6c53
    10.2217/nnm-2017-0021
    Scopus Count
    Collections
    Articles; Bioscience Program; Advanced Membranes and Porous Materials Research Center; Physical Science and Engineering (PSE) Division; Chemical Science Program; Water Desalination and Reuse Research Center (WDRC)

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