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dc.contributor.authorYue, Huifeng
dc.contributor.authorGuo, Lin
dc.contributor.authorLee, Shao-Chi
dc.contributor.authorLiu, Xiangqian
dc.contributor.authorRueping, Magnus
dc.date.accessioned2017-05-31T11:23:13Z
dc.date.available2017-05-31T11:23:13Z
dc.date.issued2017-03-21
dc.identifier.citationYue H, Guo L, Lee S-C, Liu X, Rueping M (2017) Selective Reductive Removal of Ester and Amide Groups from Arenes and Heteroarenes through Nickel-Catalyzed C−O and C−N Bond Activation. Angewandte Chemie International Edition 56: 3972–3976. Available: http://dx.doi.org/10.1002/anie.201612624.
dc.identifier.issn1433-7851
dc.identifier.doi10.1002/anie.201612624
dc.identifier.doi10.1002/ange.201612624
dc.identifier.urihttp://hdl.handle.net/10754/623907
dc.description.abstractAn inexpensive nickel(II) catalyst and a hydrosilane were used for the efficient reductive defunctionalization of aryl and heteroaryl esters through a decarbonylative pathway. This versatile method could be used for the removal of ester and amide functional groups from various organic molecules. Moreover, a scale-up experiment and a synthetic application based on the use of a removable carboxylic acid directing group highlight the usefulness of this reaction.
dc.description.sponsorshipH.Y. and L.G. acknowledge the China Scholarship Council. Support by King Abdullah University of Science and Technology (KAUST) is gratefully acknowledged.
dc.publisherWiley-Blackwell
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1002/anie.201612624/full
dc.rightsThis is the peer reviewed version of the following article: Selective Reductive Removal of Ester and Amide Groups from Arenes and Heteroarenes through Nickel-Catalyzed C-O and C-N Bond Activation, which has been published in final form at http://doi.org/10.1002/anie.201612624. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
dc.subjectamides
dc.subjectcleavage reactions
dc.subjectesters
dc.subjectnickel catalysis
dc.subjectreduction
dc.titleSelective Reductive Removal of Ester and Amide Groups from Arenes and Heteroarenes through Nickel-Catalyzed C−O and C−N Bond Activation
dc.typeArticle
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Division
dc.contributor.departmentChemical Science Program
dc.contributor.departmentKAUST Catalysis Center (KCC)
dc.identifier.journalAngewandte Chemie International Edition
dc.eprint.versionPost-print
dc.contributor.institutionInstitute of Organic Chemistry; RWTH Aachen University; Landoltweg 1 52074 Aachen Germany
kaust.personRueping, Magnus
refterms.dateFOA2018-03-21T00:00:00Z


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