Nickel-Catalyzed Synthesis of Primary Aryl and Heteroaryl Amines via C–O Bond Cleavage
KAUST DepartmentPhysical Sciences and Engineering (PSE) Division
Chemical Science Program
KAUST Catalysis Center (KCC)
Permanent link to this recordhttp://hdl.handle.net/10754/623870
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AbstractA nickel-catalyzed protocol for the conversion of aryl and heteroaryl alcohol derivatives to primary and secondary aromatic amines via C(sp2)-O bond cleavage is described. The new amination protocol can be applied to a range of substrates bearing diverse functional groups and uses readily available benzophenone imines as an effective nitrogen source.
CitationYue H, Guo L, Liu X, Rueping M (2017) Nickel-Catalyzed Synthesis of Primary Aryl and Heteroaryl Amines via C–O Bond Cleavage. Organic Letters 19: 1788–1791. Available: http://dx.doi.org/10.1021/acs.orglett.7b00556.
SponsorsH.Y., L.G., and X.L. were supported by the China Scholarship Council. Financial support by KAUST is gratefully acknowledged.
PublisherAmerican Chemical Society (ACS)