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A Microfluidic Ion Pump for In Vivo Drug Delivery

dc.contributor.authorUguz, Ilke
dc.contributor.authorProctor, Christopher M.
dc.contributor.authorCurto, Vincenzo F.
dc.contributor.authorPappa, Anna-Maria
dc.contributor.authorDonahue, Mary J.
dc.contributor.authorFerro, Magali
dc.contributor.authorOwens, Róisín M.
dc.contributor.authorKhodagholy, Dion
dc.contributor.authorInal, Sahika
dc.contributor.authorMalliaras, George G.
dc.date.accessioned2017-05-31T11:23:05Z
dc.date.available2017-05-31T11:23:05Z
dc.date.issued2017-05-15
dc.identifier.citationUguz I, Proctor CM, Curto VF, Pappa A-M, Donahue MJ, et al. (2017) A Microfluidic Ion Pump for In Vivo Drug Delivery. Advanced Materials: 1701217. Available: http://dx.doi.org/10.1002/adma.201701217.
dc.identifier.issn0935-9648
dc.identifier.pmid28503731
dc.identifier.doi10.1002/adma.201701217
dc.identifier.urihttp://hdl.handle.net/10754/623783
dc.description.abstractImplantable devices offer an alternative to systemic delivery of drugs for the treatment of neurological disorders. A microfluidic ion pump (µFIP), capable of delivering a drug without the solvent through electrophoresis, is developed. The device is characterized in vitro by delivering γ-amino butyric acid to a target solution, and demonstrates low-voltage operation, high drug-delivery capacity, and high ON/OFF ratio. It is also demonstrated that the device is suitable for cortical delivery in vivo by manipulating the local ion concentration in an animal model and altering neural behavior. These results show that µFIPs represent a significant step forward toward the development of implantable drug-delivery systems.
dc.description.sponsorshipI.U. and C.M.P. contributed equally to this work. Financial support from the Région PACA, the Whitaker Foundation, and the Fondation pour la Recherche Médicale (FRM DBS20131128446) is acknowledged. I.U. thanks Microvitae for supporting the bourse Région.
dc.publisherWiley
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1002/adma.201701217/full
dc.subjectPedot:pss
dc.subjectOrganic Bioelectronics
dc.subjectOrganic Electronic Ion Pumps
dc.titleA Microfluidic Ion Pump for In Vivo Drug Delivery
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.identifier.journalAdvanced Materials
dc.contributor.institutionDepartment of Bioelectronics; Ecole Nationale Supérieure des Mines; CMP-EMSE, MOC 13541 Gardanne France
dc.contributor.institutionDepartment of Electrical Engineering; Columbia University; NY 10027 USA
kaust.personInal, Sahika
dc.date.published-online2017-05-15
dc.date.published-print2017-07


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