Proctor, Christopher M.
Curto, Vincenzo F.
Donahue, Mary J.
Owens, Róisín M.
Malliaras, George G.
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AbstractImplantable devices offer an alternative to systemic delivery of drugs for the treatment of neurological disorders. A microfluidic ion pump (µFIP), capable of delivering a drug without the solvent through electrophoresis, is developed. The device is characterized in vitro by delivering γ-amino butyric acid to a target solution, and demonstrates low-voltage operation, high drug-delivery capacity, and high ON/OFF ratio. It is also demonstrated that the device is suitable for cortical delivery in vivo by manipulating the local ion concentration in an animal model and altering neural behavior. These results show that µFIPs represent a significant step forward toward the development of implantable drug-delivery systems.
CitationUguz I, Proctor CM, Curto VF, Pappa A-M, Donahue MJ, et al. (2017) A Microfluidic Ion Pump for In Vivo Drug Delivery. Advanced Materials: 1701217. Available: http://dx.doi.org/10.1002/adma.201701217.
SponsorsI.U. and C.M.P. contributed equally to this work. Financial support from the Région PACA, the Whitaker Foundation, and the Fondation pour la Recherche Médicale (FRM DBS20131128446) is acknowledged. I.U. thanks Microvitae for supporting the bourse Région.
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