Type
ArticleAuthors
Uguz, IlkeProctor, Christopher M.
Curto, Vincenzo F.
Pappa, Anna-Maria
Donahue, Mary J.
Ferro, Magali
Owens, Róisín M.
Khodagholy, Dion
Inal, Sahika

Malliaras, George G.

KAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionBioscience Program
Date
2017-05-15Online Publication Date
2017-05-15Print Publication Date
2017-07Permanent link to this record
http://hdl.handle.net/10754/623783
Metadata
Show full item recordAbstract
Implantable devices offer an alternative to systemic delivery of drugs for the treatment of neurological disorders. A microfluidic ion pump (µFIP), capable of delivering a drug without the solvent through electrophoresis, is developed. The device is characterized in vitro by delivering γ-amino butyric acid to a target solution, and demonstrates low-voltage operation, high drug-delivery capacity, and high ON/OFF ratio. It is also demonstrated that the device is suitable for cortical delivery in vivo by manipulating the local ion concentration in an animal model and altering neural behavior. These results show that µFIPs represent a significant step forward toward the development of implantable drug-delivery systems.Citation
Uguz I, Proctor CM, Curto VF, Pappa A-M, Donahue MJ, et al. (2017) A Microfluidic Ion Pump for In Vivo Drug Delivery. Advanced Materials: 1701217. Available: http://dx.doi.org/10.1002/adma.201701217.Sponsors
I.U. and C.M.P. contributed equally to this work. Financial support from the Région PACA, the Whitaker Foundation, and the Fondation pour la Recherche Médicale (FRM DBS20131128446) is acknowledged. I.U. thanks Microvitae for supporting the bourse Région.Publisher
WileyJournal
Advanced MaterialsPubMed ID
28503731Additional Links
http://onlinelibrary.wiley.com/doi/10.1002/adma.201701217/fullae974a485f413a2113503eed53cd6c53
10.1002/adma.201701217
Scopus Count
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