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    A Microfluidic Ion Pump for In Vivo Drug Delivery

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    Type
    Article
    Authors
    Uguz, Ilke
    Proctor, Christopher M.
    Curto, Vincenzo F.
    Pappa, Anna-Maria
    Donahue, Mary J.
    Ferro, Magali
    Owens, Róisín M.
    Khodagholy, Dion
    Inal, Sahika cc
    Malliaras, George G. cc
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Date
    2017-05-15
    Online Publication Date
    2017-05-15
    Print Publication Date
    2017-07
    Permanent link to this record
    http://hdl.handle.net/10754/623783
    
    Metadata
    Show full item record
    Abstract
    Implantable devices offer an alternative to systemic delivery of drugs for the treatment of neurological disorders. A microfluidic ion pump (µFIP), capable of delivering a drug without the solvent through electrophoresis, is developed. The device is characterized in vitro by delivering γ-amino butyric acid to a target solution, and demonstrates low-voltage operation, high drug-delivery capacity, and high ON/OFF ratio. It is also demonstrated that the device is suitable for cortical delivery in vivo by manipulating the local ion concentration in an animal model and altering neural behavior. These results show that µFIPs represent a significant step forward toward the development of implantable drug-delivery systems.
    Citation
    Uguz I, Proctor CM, Curto VF, Pappa A-M, Donahue MJ, et al. (2017) A Microfluidic Ion Pump for In Vivo Drug Delivery. Advanced Materials: 1701217. Available: http://dx.doi.org/10.1002/adma.201701217.
    Sponsors
    I.U. and C.M.P. contributed equally to this work. Financial support from the Région PACA, the Whitaker Foundation, and the Fondation pour la Recherche Médicale (FRM DBS20131128446) is acknowledged. I.U. thanks Microvitae for supporting the bourse Région.
    Publisher
    Wiley
    Journal
    Advanced Materials
    DOI
    10.1002/adma.201701217
    PubMed ID
    28503731
    Additional Links
    http://onlinelibrary.wiley.com/doi/10.1002/adma.201701217/full
    ae974a485f413a2113503eed53cd6c53
    10.1002/adma.201701217
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program

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