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dc.contributor.authorNielsen, Jens
dc.contributor.authorArcher, John A.C.
dc.contributor.authorEssack, Magbubah
dc.contributor.authorBajic, Vladimir B.
dc.contributor.authorGojobori, Takashi
dc.contributor.authorMijakovic, Ivan
dc.date.accessioned2017-05-25T10:55:13Z
dc.date.available2017-05-25T10:55:13Z
dc.date.issued2017-05-20
dc.identifier.citationNielsen J, Archer J, Essack M, Bajic VB, Gojobori T, et al. (2017) Building a bio-based industry in the Middle East through harnessing the potential of the Red Sea biodiversity. Applied Microbiology and Biotechnology. Available: http://dx.doi.org/10.1007/s00253-017-8310-9.
dc.identifier.issn0175-7598
dc.identifier.issn1432-0614
dc.identifier.pmid28528426
dc.identifier.doi10.1007/s00253-017-8310-9
dc.identifier.urihttp://hdl.handle.net/10754/623708
dc.description.abstractThe incentive for developing microbial cell factories for production of fuels and chemicals comes from the ability of microbes to deliver these valuable compounds at a reduced cost and with a smaller environmental impact compared to the analogous chemical synthesis. Another crucial advantage of microbes is their great biological diversity, which offers a much larger “catalog” of molecules than the one obtainable by chemical synthesis. Adaptation to different environments is one of the important drives behind microbial diversity. We argue that the Red Sea, which is a rather unique marine niche, represents a remarkable source of biodiversity that can be geared towards economical and sustainable bioproduction processes in the local area and can be competitive in the international bio-based economy. Recent bioprospecting studies, conducted by the King Abdullah University of Science and Technology, have established important leads on the Red Sea biological potential, with newly isolated strains of Bacilli and Cyanobacteria. We argue that these two groups of local organisms are currently most promising in terms of developing cell factories, due to their ability to operate in saline conditions, thus reducing the cost of desalination and sterilization. The ability of Cyanobacteria to perform photosynthesis can be fully exploited in this particular environment with one of the highest levels of irradiation on the planet. We highlight the importance of new experimental and in silico methodologies needed to overcome the hurdles of developing efficient cell factories from the Red Sea isolates.
dc.description.sponsorshipWe acknowledge funding from the Novo Nordisk Foundation (to JN and IM), the Knut and Alice Wallenberg Foundation (to JN) and Vetenskapsrådet (to JN), the King Abdullah University of Science and Technology (KAUST) Office of Sponsored Research (OSR) under Awards No URF/1/2302 and No URF/1/1976-02, and KAUST Base Research Fund (BAS/1/1606-01-01) to VBB.
dc.publisherSpringer Nature
dc.relation.urlhttp://link.springer.com/article/10.1007%2Fs00253-017-8310-9
dc.rightsThe final publication is available at Springer via http://dx.doi.org/10.1007/s00253-017-8310-9
dc.subjectMetabolic engineering
dc.subjectSynthetic biology
dc.subjectIndustrial biotechnology
dc.subjectCell factories
dc.subjectMetagenomics
dc.titleBuilding a bio-based industry in the Middle East through harnessing the potential of the Red Sea biodiversity
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentPathogen Genomics Laboratory
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentApplied Mathematics and Computational Science Program
dc.contributor.departmentBioscience Program
dc.identifier.journalApplied Microbiology and Biotechnology
dc.eprint.versionPost-print
dc.contributor.institutionDepartment of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden
dc.contributor.institutionNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark
dc.contributor.institutionScience for Life Laboratory, Royal Institute of Technology, Solna, Sweden
kaust.personArcher, John A.C.
kaust.personEssack, Magbubah
kaust.personBajic, Vladimir B.
kaust.personGojobori, Takashi
kaust.grant.numberURF/1/2302
kaust.grant.numberURF/1/1976-02
kaust.grant.numberBAS/1/1606-01-01
refterms.dateFOA2018-05-20T00:00:00Z
dc.date.published-online2017-05-20
dc.date.published-print2017-06


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