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    Building a bio-based industry in the Middle East through harnessing the potential of the Red Sea biodiversity

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    art3A10.10072Fs00253-017-8310-9.pdf
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    Description:
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    Type
    Article
    Authors
    Nielsen, Jens
    Archer, John A.C. cc
    Essack, Magbubah cc
    Bajic, Vladimir B. cc
    Gojobori, Takashi cc
    Mijakovic, Ivan
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Pathogen Genomics Laboratory
    Computational Bioscience Research Center (CBRC)
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    Applied Mathematics and Computational Science Program
    Bioscience Program
    KAUST Grant Number
    URF/1/2302
    URF/1/1976-02
    BAS/1/1606-01-01
    Date
    2017-05-20
    Online Publication Date
    2017-05-20
    Print Publication Date
    2017-06
    Permanent link to this record
    http://hdl.handle.net/10754/623708
    
    Metadata
    Show full item record
    Abstract
    The incentive for developing microbial cell factories for production of fuels and chemicals comes from the ability of microbes to deliver these valuable compounds at a reduced cost and with a smaller environmental impact compared to the analogous chemical synthesis. Another crucial advantage of microbes is their great biological diversity, which offers a much larger “catalog” of molecules than the one obtainable by chemical synthesis. Adaptation to different environments is one of the important drives behind microbial diversity. We argue that the Red Sea, which is a rather unique marine niche, represents a remarkable source of biodiversity that can be geared towards economical and sustainable bioproduction processes in the local area and can be competitive in the international bio-based economy. Recent bioprospecting studies, conducted by the King Abdullah University of Science and Technology, have established important leads on the Red Sea biological potential, with newly isolated strains of Bacilli and Cyanobacteria. We argue that these two groups of local organisms are currently most promising in terms of developing cell factories, due to their ability to operate in saline conditions, thus reducing the cost of desalination and sterilization. The ability of Cyanobacteria to perform photosynthesis can be fully exploited in this particular environment with one of the highest levels of irradiation on the planet. We highlight the importance of new experimental and in silico methodologies needed to overcome the hurdles of developing efficient cell factories from the Red Sea isolates.
    Citation
    Nielsen J, Archer J, Essack M, Bajic VB, Gojobori T, et al. (2017) Building a bio-based industry in the Middle East through harnessing the potential of the Red Sea biodiversity. Applied Microbiology and Biotechnology. Available: http://dx.doi.org/10.1007/s00253-017-8310-9.
    Sponsors
    We acknowledge funding from the Novo Nordisk Foundation (to JN and IM), the Knut and Alice Wallenberg Foundation (to JN) and Vetenskapsrådet (to JN), the King Abdullah University of Science and Technology (KAUST) Office of Sponsored Research (OSR) under Awards No URF/1/2302 and No URF/1/1976-02, and KAUST Base Research Fund (BAS/1/1606-01-01) to VBB.
    Publisher
    Springer Nature
    Journal
    Applied Microbiology and Biotechnology
    DOI
    10.1007/s00253-017-8310-9
    PubMed ID
    28528426
    Additional Links
    http://link.springer.com/article/10.1007%2Fs00253-017-8310-9
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00253-017-8310-9
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program; Applied Mathematics and Computational Science Program; Computational Bioscience Research Center (CBRC); Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division

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