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    A remotely operated drug delivery system with dose control

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    Type
    Article
    Authors
    Yi, Ying
    Kosel, Jürgen cc
    KAUST Department
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    Electrical Engineering Program
    Date
    2017-05-08
    Online Publication Date
    2017-05-08
    Print Publication Date
    2017-07
    Permanent link to this record
    http://hdl.handle.net/10754/623672
    
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    Abstract
    “On demand” implantable drug delivery systems can provide optimized treatments, due to their ability to provide targeted, flexible and precise dose release. However, two important issues that need to be carefully considered in a mature device include an effective actuation stimulus and a controllable dose release mechanism. This work focuses on remotely powering an implantable drug delivery system and providing a high degree of control over the released dose. This is accomplished by integration of a resonance-based wireless power transfer system, a constant voltage control circuit and an electrolytic pump. Upon the activation of the wireless power transfer system, the electrolytic actuator is remotely powered by a constant voltage regardless of movements of the device within an effective range of translation and rotation. This in turn contributes to a predictable dose release rate and greater flexibility in the positioning of external powering source. We have conducted proof-of-concept drug delivery studies using the liquid drug in reservoir approach and the solid drug in reservoir approach, respectively. Our experimental results demonstrate that the range of flow rate is mainly determined by the voltage controlled with a Zener diode and the resistance of the implantable device. The latter can be adjusted by connecting different resistors, providing control over the flow rate to meet different clinical needs. The flow rate can be maintained at a constant level within the effective movement range. When using a solid drug substitute with a low solubility, solvent blue 38, the dose release can be kept at 2.36μg/cycle within the effective movement range by using an input voltage of 10Vpp and a load of 1.5 kΩ, which indicates the feasibility and controllability of our system without any complicated closed-loop sensor.
    Citation
    Yi Y, Kosel J (2017) A remotely operated drug delivery system with dose control. Sensors and Actuators A: Physical 261: 177–183. Available: http://dx.doi.org/10.1016/j.sna.2017.05.007.
    Publisher
    Elsevier BV
    Journal
    Sensors and Actuators A: Physical
    DOI
    10.1016/j.sna.2017.05.007
    Additional Links
    http://www.sciencedirect.com/science/article/pii/S0924424717308087
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.sna.2017.05.007
    Scopus Count
    Collections
    Articles; Electrical Engineering Program; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

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