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    Conducting Polymer Scaffolds for Hosting and Monitoring 3D Cell Culture

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    Type
    Article
    Authors
    Inal, Sahika cc
    Hama, Adel
    Ferro, Magali
    Pitsalidis, Charalampos
    Oziat, Julie
    Iandolo, Donata
    Pappa, Anna-Maria
    Hadida, Mikhael
    Huerta, Miriam
    Marchat, David
    Mailley, Pascal
    Owens, Róisín M.
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Date
    2017-05-03
    Online Publication Date
    2017-05-03
    Print Publication Date
    2017-06
    Permanent link to this record
    http://hdl.handle.net/10754/623658
    
    Metadata
    Show full item record
    Abstract
    This work reports the design of a live-cell monitoring platform based on a macroporous scaffold of a conducting polymer, poly(3,4-ethylene dioxythiophene):poly(styrenesulfonate). The conducting polymer scaffolds support 3D cell cultures due to their biocompatibility and tissue-like elasticity, which can be manipulated by inclusion of biopolymers such as collagen. Integration of a media perfusion tube inside the scaffold enables homogenous cell spreading and fluid transport throughout the scaffold, ensuring long term cell viability. This also allows for co-culture of multiple cell types inside the scaffold. The inclusion of cells within the porous architecture affects the impedance of the electrically conducting polymer network and, thus, is utilized as an in situ tool to monitor cell growth. Therefore, while being an integral part of the 3D tissue, the conducting polymer is an active component, enhancing the tissue function, and forming the basis for a bioelectronic device with integrated sensing capability.
    Citation
    Inal S, Hama A, Ferro M, Pitsalidis C, Oziat J, et al. (2017) Conducting Polymer Scaffolds for Hosting and Monitoring 3D Cell Culture. Advanced Biosystems: 1700052. Available: http://dx.doi.org/10.1002/adbi.201700052.
    Sponsors
    S.I. and C.P. gratefully acknowledge financial support from the ANR 3Bs project. This work was also supported by the Marie Curie ITN project OrgBio No. 607896. S.I. and A.H. benefitted from fruitful discussions with Professor Gordon Wallace at the University of Wollongong thanks to visits funded by the Marie Curie MASK project No. 269302, and from Dr. Pierre Leleux (EMSE) and Dr. Ilke Uguz (EMSE) related to device fabrication.
    Publisher
    Wiley
    Journal
    Advanced Biosystems
    DOI
    10.1002/adbi.201700052
    10.1002/adbi.201770038
    ae974a485f413a2113503eed53cd6c53
    10.1002/adbi.201700052
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program

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