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    Sparsity-based multi-height phase recovery in holographic microscopy

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    Type
    Article
    Authors
    Rivenson, Yair
    Wu, Yichen
    Wang, Hongda
    Zhang, Yibo
    Feizi, Alborz
    Ozcan, Aydogan cc
    Date
    2016-11-30
    Online Publication Date
    2016-11-30
    Print Publication Date
    2016-12
    Permanent link to this record
    http://hdl.handle.net/10754/623595
    
    Metadata
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    Abstract
    High-resolution imaging of densely connected samples such as pathology slides using digital in-line holographic microscopy requires the acquisition of several holograms, e.g., at >6–8 different sample-to-sensor distances, to achieve robust phase recovery and coherent imaging of specimen. Reducing the number of these holographic measurements would normally result in reconstruction artifacts and loss of image quality, which would be detrimental especially for biomedical and diagnostics-related applications. Inspired by the fact that most natural images are sparse in some domain, here we introduce a sparsity-based phase reconstruction technique implemented in wavelet domain to achieve at least 2-fold reduction in the number of holographic measurements for coherent imaging of densely connected samples with minimal impact on the reconstructed image quality, quantified using a structural similarity index. We demonstrated the success of this approach by imaging Papanicolaou smears and breast cancer tissue slides over a large field-of-view of ~20 mm2 using 2 in-line holograms that are acquired at different sample-to-sensor distances and processed using sparsity-based multi-height phase recovery. This new phase recovery approach that makes use of sparsity can also be extended to other coherent imaging schemes, involving e.g., multiple illumination angles or wavelengths to increase the throughput and speed of coherent imaging.
    Citation
    Rivenson Y, Wu Y, Wang H, Zhang Y, Feizi A, et al. (2016) Sparsity-based multi-height phase recovery in holographic microscopy. Scientific Reports 6. Available: http://dx.doi.org/10.1038/srep37862.
    Sponsors
    The Ozcan Research Group at UCLA gratefully acknowledges the support of the Presidential Early Career Award for Scientists and Engineers (PECASE), the Army Research Office (ARO; W911NF-13–1–0419 and W911NF-13-1-0197), the ARO Life Sciences Division, the National Science Foundation (NSF) CBET Division Biophotonics Program, the NSF Emerging Frontiers in Research and Innovation (EFRI) Award, the NSF EAGER Award, NSF INSPIRE Award, NSF Partnerships for Innovation: Building Innovation Capacity (PFI:BIC) Program, Office of Naval Research (ONR), the National Institutes of Health (NIH), the Howard Hughes Medical Institute (HHMI), Vodafone Americas Foundation, the Mary Kay Foundation, Steven & Alexandra Cohen Foundation, and KAUST. This work is based upon research performed in a laboratory renovated by the National Science Foundation under Grant No. 0963183, which is an award funded under the American Recovery and Reinvestment Act of 2009 (ARRA). Furthermore, Yair Rivenson is supported by the European Union’s Horizon 2020 research and innovation programme under grant agreement No H2020-MSCA-IF-2014-659595 (MCMQCT).
    Publisher
    Springer Nature
    Journal
    Scientific Reports
    DOI
    10.1038/srep37862
    Additional Links
    http://www.nature.com/articles/srep37862
    ae974a485f413a2113503eed53cd6c53
    10.1038/srep37862
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