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dc.contributor.authorXue, Chuan
dc.contributor.authorOthmer, Hans G.
dc.contributor.authorErban, Radek
dc.date.accessioned2017-05-15T10:35:07Z
dc.date.available2017-05-15T10:35:07Z
dc.date.issued2009-09-23
dc.identifier.citationXue C, Othmer HG, Erban R, Sinclair RM, Stiefel KM (2009) From Individual to Collective Behavior of Unicellular Organisms: Recent Results and Open Problems. AIP Conference Proceedings. Available: http://dx.doi.org/10.1063/1.3246413.
dc.identifier.doi10.1063/1.3246413
dc.identifier.urihttp://hdl.handle.net/10754/623545
dc.description.abstractThe collective movements of unicellular organisms such as bacteria or amoeboid (crawling) cells are often modeled by partial differential equations (PDEs) that describe the time evolution of cell density. In particular, chemotaxis equations have been used to model the movement towards various kinds of extracellular cues. Well-developed analytical and numerical methods for analyzing the time-dependent and time-independent properties of solutions make this approach attractive. However, these models are often based on phenomenological descriptions of cell fluxes with no direct correspondence to individual cell processes such signal transduction and cell movement. This leads to the question of how to justify these macroscopic PDEs from microscopic descriptions of cells, and how to relate the macroscopic quantities in these PDEs to individual-level parameters. Here we summarize recent progress on this question in the context of bacterial and amoeboid chemotaxis, and formulate several open problems.
dc.description.sponsorshipThis research was supported in part by NSF Grant DMS # 0817529 and NIH Grant 02911123 (HGO), by the Mathematical Biosciences Institute via a post-doctoral fellowship (CX) and by Somerville College, University of Oxford (RE). This publication is based on work supported by Award No. KUK-Cl-013-04, made by King Abdullah University of Science and Technology (KAUST) (RE).
dc.publisherAIP Publishing
dc.titleFrom Individual to Collective Behavior of Unicellular Organisms: Recent Results and Open Problems
dc.typeConference Paper
dc.identifier.journalAIP Conference Proceedings
dc.conference.date2008-11-04 to 2008-11-06
dc.conference.name2nd Conference on Mathematics and Biology: Multiscale Phenomena in Biology
dc.conference.locationOkinawa, JPN
dc.contributor.institutionMathematical Biosciences Institute, Oliio State University, Columbus, OH 43210, USA
dc.contributor.institutionSchool of Mathematics, University of Minnesota, Minneapolis, MN 55455, USA
dc.contributor.institutionMathematical Institute, University of Oxford, 24-29 St Giles', Oxford, 0X1 3LB, UK
kaust.grant.numberKUK-Cl-013-04
dc.date.published-online2009-09-23
dc.date.published-print2009


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