Thielavins W–Z7, New Antifouling Thielavins from the Marine-Derived Fungus Thielavia sp. UST030930-004
KAUST DepartmentImaging & Characterization Core lab, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia. firstname.lastname@example.org.
Physical Sciences and Engineering (PSE) Division
MetadataShow full item record
AbstractEleven new depsides-thielavins W-Z (1-4) and thielavins Z₁-Z₇ (5-11)-and also four known thielavins-A, H, J, and K (12-15)-were isolated from the ethyl acetate extract of a marine-derived fungal strain Thielavia sp UST030930-004. All of these compounds were evaluated for antifouling activity against cyprids of the barnacle Balanus (=Amphibalanus) amphitrite. The results showed that compounds 1-3 and 6-13 were active, with EC50 values ranging from 2.95 ± 0.59 to 69.19 ± 9.51 μM, respectively. The inhibitive effect of compounds 1-3 and 7 was reversible. This is the first description of the antifouling activity of thielavins against barnacle cyprids.
CitationHan Z, Li Y-X, Liu L-L, Lu L, Guo X-R, et al. (2017) Thielavins W–Z7, New Antifouling Thielavins from the Marine-Derived Fungus Thielavia sp. UST030930-004. Marine Drugs 15: 128. Available: http://dx.doi.org/10.3390/md15050128.
SponsorsWe are grateful for the financial support from the China Ocean Mineral Resources Research and Development Association (DY135), Youth Innovation Promotion Association CAS (QC2015388), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB06010204), Hainan Special Project for Ocean Exploration (XH201410), the Natural Science Foundation of Hainan Province (414186), and Institute of Deep-Sea Science and Engineering (SIDSSE-QN-201303).
Except where otherwise noted, this item's license is described as This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
- Antifouling activity of secondary metabolites isolated from chinese marine organisms.
- Authors: Li YX, Wu HX, Xu Y, Shao CL, Wang CY, Qian PY
- Issue date: 2013 Oct
- Cochliomycin A inhibits the larval settlement of Amphibalanus amphitrite by activating the NO/cGMP pathway.
- Authors: Wang KL, Zhang G, Sun J, Xu Y, Han Z, Liu LL, Shao CL, Liu QA, Wang CY, Qian PY
- Issue date: 2016
- Antifouling Compounds from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162.
- Authors: Nong XH, Zhang XY, Xu XY, Qi SH
- Issue date: 2015 Jun
- New Marine Antifouling Compounds from the Red Alga Laurencia sp.
- Authors: Oguri Y, Watanabe M, Ishikawa T, Kamada T, Vairappan CS, Matsuura H, Kaneko K, Ishii T, Suzuki M, Yoshimura E, Nogata Y, Okino T
- Issue date: 2017 Aug 28
- Potent Antifouling Marine Dihydroquinolin-2(1H)-one-Containing Alkaloids from the Gorgonian Coral-Derived Fungus Scopulariopsis sp.
- Authors: Shao CL, Xu RF, Wang CY, Qian PY, Wang KL, Wei MY
- Issue date: 2015 Aug