Thielavins W–Z7, New Antifouling Thielavins from the Marine-Derived Fungus Thielavia sp. UST030930-004

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Type
Article
Authors
Han, Zhuang
Li, Yong-Xin
Liu, Ling-Li
Lu, Liang
Guo, Xianrong
Zhang, Xixiang cc
Zhang, Xiao-Yong
Qi, Shu-Hua
Xu, Ying
Qian, Pei-Yuan cc
KAUST Department
Imaging & Characterization Core lab, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia. xianrong.guo@kaust.edu.sa.
Material Science and Engineering Program
NMR
Physical Science and Engineering (PSE) Division
Date
2017-04-29
Permanent link to this record
http://hdl.handle.net/10754/623417

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Abstract
Eleven new depsides-thielavins W-Z (1-4) and thielavins Z₁-Z₇ (5-11)-and also four known thielavins-A, H, J, and K (12-15)-were isolated from the ethyl acetate extract of a marine-derived fungal strain Thielavia sp UST030930-004. All of these compounds were evaluated for antifouling activity against cyprids of the barnacle Balanus (=Amphibalanus) amphitrite. The results showed that compounds 1-3 and 6-13 were active, with EC50 values ranging from 2.95 ± 0.59 to 69.19 ± 9.51 μM, respectively. The inhibitive effect of compounds 1-3 and 7 was reversible. This is the first description of the antifouling activity of thielavins against barnacle cyprids.
Citation
Han Z, Li Y-X, Liu L-L, Lu L, Guo X-R, et al. (2017) Thielavins W–Z7, New Antifouling Thielavins from the Marine-Derived Fungus Thielavia sp. UST030930-004. Marine Drugs 15: 128. Available: http://dx.doi.org/10.3390/md15050128.
Sponsors
We are grateful for the financial support from the China Ocean Mineral Resources Research and Development Association (DY135), Youth Innovation Promotion Association CAS (QC2015388), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB06010204), Hainan Special Project for Ocean Exploration (XH201410), the Natural Science Foundation of Hainan Province (414186), and Institute of Deep-Sea Science and Engineering (SIDSSE-QN-201303).
Publisher
MDPI AG
Journal
Marine Drugs
DOI
10.3390/md15050128
PubMed ID
28468259
Additional Links
http://www.mdpi.com/1660-3397/15/5/128
Collections
Articles; Physical Science and Engineering (PSE) Division; Material Science and Engineering Program
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
Except where otherwise noted, this item's license is described as This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).