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    Multiple Scattering Model for Optical Coherence Tomography with Rytov Approximation

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    Type
    Thesis
    Authors
    Li, Muxingzi cc
    Advisors
    Heidrich, Wolfgang cc
    Committee members
    Sundaramoorthi, Ganesh cc
    Leiknes, TorOve cc
    Program
    Applied Mathematics and Computational Science
    KAUST Department
    Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division
    Date
    2017-04-24
    Permanent link to this record
    http://hdl.handle.net/10754/623270
    
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    Abstract
    Optical Coherence Tomography (OCT) is a coherence-gated, micrometer-resolution imaging technique that focuses a broadband near-infrared laser beam to penetrate into optical scattering media, e.g. biological tissues. The OCT resolution is split into two parts, with the axial resolution defined by half the coherence length, and the depth-dependent lateral resolution determined by the beam geometry, which is well described by a Gaussian beam model. The depth dependence of lateral resolution directly results in the defocusing effect outside the confocal region and restricts current OCT probes to small numerical aperture (NA) at the expense of lateral resolution near the focus. Another limitation on OCT development is the presence of a mixture of speckles due to multiple scatterers within the coherence length, and other random noise. Motivated by the above two challenges, a multiple scattering model based on Rytov approximation and Gaussian beam optics is proposed for the OCT setup. Some previous papers have adopted the first Born approximation with the assumption of small perturbation of the incident field in inhomogeneous media. The Rytov method of the same order with smooth phase perturbation assumption benefits from a wider spatial range of validity. A deconvolution method for solving the inverse problem associated with the first Rytov approximation is developed, significantly reducing the defocusing effect through depth and therefore extending the feasible range of NA.
    Citation
    Li, M. (2017). Multiple Scattering Model for Optical Coherence Tomography with Rytov Approximation. KAUST Research Repository. https://doi.org/10.25781/KAUST-B4Z34
    DOI
    10.25781/KAUST-B4Z34
    ae974a485f413a2113503eed53cd6c53
    10.25781/KAUST-B4Z34
    Scopus Count
    Collections
    Applied Mathematics and Computational Science Program; MS Theses; Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division

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