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    Progenitor strain introduction of Mycobacterium bovis at the wildlife-livestock interface can lead to clonal expansion of the disease in a single ecosystem

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    Type
    Article
    Authors
    Dippenaar, Anzaan
    Parsons, Sven David Charles
    Miller, Michele Ann
    Hlokwe, Tiny
    van Pittius, Nicolaas Claudius Gey
    Adroub, Sabir
    Abdallah, Abdallah
    Pain, Arnab cc
    Warren, Robin Mark
    Michel, Anita Luise
    van Helden, Paul David
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Core Lab
    Bioscience Program
    NGS, qPCR and Single Cell Genomics
    Pathogen Genomics Laboratory
    Date
    2017-04-13
    Online Publication Date
    2017-04-13
    Print Publication Date
    2017-07
    Permanent link to this record
    http://hdl.handle.net/10754/623266
    
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    Abstract
    Mycobacterium bovis infects multiple wildlife species and domesticated cattle across South Africa, and negatively impacts on livestock trade and movement of wildlife for conservation purposes. M. bovis infection was first reported in the Kruger National Park (KNP) in South Africa during the 1990s, and has since spread to infect numerous animal host species throughout the park and across South Africa. Whole genome sequencing data of 17 M. bovis isolates were analyzed to investigate the genomic diversity among M. bovis isolates causing disease in different animal host species from various locations in South Africa. M. bovis strains analyzed in this study are geographic rather than host species-specific. The clonal expansion of M. bovis in the KNP highlights the effect of an introduction of a transmissible infectious disease leading to a rising epidemic in wildlife, and emphasizes the importance of disease control and movement restriction of species that serve as disease reservoirs. In conclusion, the point source introduction of a single M. bovis strain type in the KNP ecosystem lead to an M. bovis outbreak in this area that affects various host species and poses an infection risk in neighboring rural communities where HIV prevalence is high.
    Citation
    Dippenaar A, Parsons SDC, Miller MA, Hlokwe T, van Pittius NCG, et al. (2017) Progenitor strain introduction of Mycobacterium bovis at the wildlife-livestock interface can lead to clonal expansion of the disease in a single ecosystem. Infection, Genetics and Evolution. Available: http://dx.doi.org/10.1016/j.meegid.2017.04.012.
    Sponsors
    This study was enabled by funding from the South African Medical Research Council, the National Research Foundation, and faculty baseline funding from King Abdullah University of Science and Technology (KAUST, Thuwal, Saudi Arabia) awarded to A Pain. MA Miller is funded by the South African Research Chairs Initiative of the Department of Science and Technology and National Research Foundation (NRF) of South Africa, award number UID 86949. Any opinion, finding and conclusion or recommendation expressed in this material is that of the author(s) and the NRF does not accept any liability in this regard. The authors declare that no conflict of interest exists.
    Publisher
    Elsevier BV
    Journal
    Infection, Genetics and Evolution
    DOI
    10.1016/j.meegid.2017.04.012
    Additional Links
    http://www.sciencedirect.com/science/article/pii/S1567134817301259
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.meegid.2017.04.012
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program; Bioscience Core Lab

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