Catalytic Ester and Amide to Amine Interconversion: Nickel-Catalyzed Decarbonylative Amination of Esters and Amides by C−O and C−C Bond Activation
KAUST DepartmentPhysical Sciences and Engineering (PSE) Division
Chemical Science Program
KAUST Catalysis Center (KCC)
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AbstractAn efficient nickel-catalyzed decarbonylative amination reaction of aryl and heteroaryl esters has been achieved for the first time. The new amination protocol allows the direct interconversion of esters and amides into the corresponding amines and represents a good alternative to classical rearrangements as well as cross coupling reactions.
CitationYue H, Guo L, Liao H-H, Cai Y, Zhu C, et al. (2017) Catalytic Ester and Amide to Amine Interconversion: Nickel-Catalyzed Decarbonylative Amination of Esters and Amides by C−O and C−C Bond Activation. Angewandte Chemie International Edition 56: 4282–4285. Available: http://dx.doi.org/10.1002/anie.201611819.
SponsorsH.Y. and L.G. acknowledge the China Scholarship Council. H.-H.L. acknowledges the DAAD for a doctoral fellowship, Y.C. acknowledges the Alexander von Humboldt-Foundation for a fellowship. Support by King Abdullah University of Science and Technology (KAUST) is gratefully acknowledged.