Type
Book ChapterKAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionPhysical Science and Engineering (PSE) Division
Date
2017-02-23Online Publication Date
2017-02-23Print Publication Date
2017Permanent link to this record
http://hdl.handle.net/10754/623194
Metadata
Show full item recordAbstract
For many years, myocardial tissue has been considered terminally differentiated and, thus, incapable of regenerating. Recent studies have shown, instead, that cardiomyocytes, at least in part, are slowly substituted by new cells originating by precursor cells mostly embedded into the heart apex and in the atria. We have shown that an elective region of progenitor cell embedding is represented by the auricles, non-contractile atria appendages that can be easily sampled without harming the patient. The protocol here reported describes how from auricles a population of multipotent, cardiogenic cells can be isolated, cultured, and differentiated. Further studies are needed to fully exploit this cell population, but, sampling auricles, it could be possible to treat cardiac patients using their own cells circumventing rejection or organ shortage limitations.Citation
Di Nardo P, Pagliari F (2017) Cardiac Progenitor Cell Extraction from Human Auricles. Methods in Molecular Biology: 145–154. Available: http://dx.doi.org/10.1007/978-1-4939-6756-8_11.Publisher
Springer NatureJournal
Methods in Molecular BiologyAdditional Links
http://link.springer.com/chapter/10.1007/978-1-4939-6756-8_11ae974a485f413a2113503eed53cd6c53
10.1007/978-1-4939-6756-8_11