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    Cellular Internalization and Biocompatibility of Periodic Mesoporous Organosilica Nanoparticles with Tunable Morphologies: From Nanospheres to Nanowires

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    Type
    Article
    Authors
    Fatieiev, Yevhen cc
    Croissant, Jonas G.
    Alamoudi, Kholod cc
    Khashab, Niveen M. cc
    KAUST Department
    Advanced Membranes and Porous Materials Research Center
    Bioscience Program
    Chemical Science Program
    Investment Fund
    Physical Science and Engineering (PSE) Division
    Smart Hybrid Materials (SHMs) lab
    Date
    2017-01-31
    Online Publication Date
    2017-01-31
    Print Publication Date
    2017-04
    Permanent link to this record
    http://hdl.handle.net/10754/623170
    
    Metadata
    Show full item record
    Abstract
    This work describes the sol-gel syntheses of para-substituted phenylene-bridged periodic mesoporous organosilica (PMO) nanoparticles (NPs) with tunable morphologies ranging from nanowires to nanospheres. The findings show the key role of the addition of organic co-solvents in the aqueous templates on the final morphologies of PMO NPs. Other factors such as the temperature, the stirring speed, and the amount of organic solvents also influence the shape of PMO NPs. The tuning of the shape of the PMO nanomaterials made it possible to study the influence of the particle morphology on the cellular internalization and biocompatibility.
    Citation
    Fatieiev Y, Croissant JG, Alamoudi K, Khashab NM (2017) Cellular Internalization and Biocompatibility of Periodic Mesoporous Organosilica Nanoparticles with Tunable Morphologies: From Nanospheres to Nanowires. ChemPlusChem. Available: http://dx.doi.org/10.1002/cplu.201600560.
    Sponsors
    We gratefully acknowledge support from King Abdullah University of Science and Technology (KAUST), and NSF Grant DBI-1266377. We thank Haneen Omar for her support in the XRD measurements.
    Publisher
    Wiley
    Journal
    ChemPlusChem
    DOI
    10.1002/cplu.201600560
    Additional Links
    http://onlinelibrary.wiley.com/doi/10.1002/cplu.201600560/full
    ae974a485f413a2113503eed53cd6c53
    10.1002/cplu.201600560
    Scopus Count
    Collections
    Articles; Bioscience Program; Advanced Membranes and Porous Materials Research Center; Physical Science and Engineering (PSE) Division; Controlled Release and Delivery Laboratory; Chemical Science Program

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