Cellular Internalization and Biocompatibility of Periodic Mesoporous Organosilica Nanoparticles with Tunable Morphologies: From Nanospheres to Nanowires
KAUST DepartmentAdvanced Membranes and Porous Materials Research Center
Smart Hybrid Materials (SHMs) lab
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AbstractThis work describes the sol-gel syntheses of para-substituted phenylene-bridged periodic mesoporous organosilica (PMO) nanoparticles (NPs) with tunable morphologies ranging from nanowires to nanospheres. The findings show the key role of the addition of organic co-solvents in the aqueous templates on the final morphologies of PMO NPs. Other factors such as the temperature, the stirring speed, and the amount of organic solvents also influence the shape of PMO NPs. The tuning of the shape of the PMO nanomaterials made it possible to study the influence of the particle morphology on the cellular internalization and biocompatibility.
CitationFatieiev Y, Croissant JG, Alamoudi K, Khashab NM (2017) Cellular Internalization and Biocompatibility of Periodic Mesoporous Organosilica Nanoparticles with Tunable Morphologies: From Nanospheres to Nanowires. ChemPlusChem. Available: http://dx.doi.org/10.1002/cplu.201600560.
SponsorsWe gratefully acknowledge support from King Abdullah University of Science and Technology (KAUST), and NSF Grant DBI-1266377. We thank Haneen Omar for her support in the XRD measurements.