Magneto-Plasmonic Janus Vesicles for Magnetic Field-Enhanced Photoacoustic and Magnetic Resonance Imaging of Tumors
Type
ArticleAuthors
Liu, YijingYang, Xiangyu
Huang, Zhiqi
Huang, Peng
Zhang, Yang
Deng, Lin

Wang, Zhantong
Zhou, Zijian
Liu, Yi

Kalish, Heather
Khashab, Niveen M.

Chen, Xiaoyuan
Nie, Zhihong

KAUST Department
Advanced Membranes and Porous Materials Research CenterChemical Science Program
Physical Science and Engineering (PSE) Division
Smart Hybrid Materials (SHMs) lab
KAUST Grant Number
CRG-2015Date
2016-11-10Online Publication Date
2016-11-09Print Publication Date
2016-12-05Embargo End Date
2017-11-10Permanent link to this record
http://hdl.handle.net/10754/623166
Metadata
Show full item recordAbstract
Magneto-plasmonic Janus vesicles (JVs) integrated with gold nanoparticles (AuNPs) and magnetic NPs (MNPs) were prepared asymmetrically in the membrane for in vivo cancer imaging. The hybrid JVs were produced by coassembling a mixture of hydrophobic MNPs, free amphiphilic block copolymers (BCPs), and AuNPs tethered with amphiphilic BCPs. Depending on the size and content of NPs, the JVs acquired spherical or hemispherical shapes. Among them, hemispherical JVs containing 50 nm AuNPs and 15 nm MNPs showed a strong absorption in the near-infrared (NIR) window and enhanced the transverse relaxation (T2) contrast effect, as a result of the ordering and dense packing of AuNPs and MNPs in the membrane. The magneto-plasmonic JVs were used as drug delivery vehicles, from which the release of a payload can be triggered by NIR light and the release rate can be modulated by a magnetic field. Moreover, the JVs were applied as imaging agents for in vivo bimodal photoacoustic (PA) and magnetic resonance (MR) imaging of tumors by intravenous injection. With an external magnetic field, the accumulation of the JVs in tumors was significantly increased, leading to a signal enhancement of approximately 2–3 times in the PA and MR imaging, compared with control groups without a magnetic field.Citation
Liu Y, Yang X, Huang Z, Huang P, Zhang Y, et al. (2016) Magneto-Plasmonic Janus Vesicles for Magnetic Field-Enhanced Photoacoustic and Magnetic Resonance Imaging of Tumors. Angewandte Chemie International Edition 55: 15297–15300. Available: http://dx.doi.org/10.1002/anie.201608338.Sponsors
Z.N. gratefully acknowledges the financial support of the National Science Foundation (grants: DMR-1255377, CHE-1505839) and 3M Non-tenured Faculty Award. N.M.K. and Z.N. further acknowledge support provided by a King Abdullah University of Science and Technology CRG-2015 grant. The work was also supported by the Intramural Research Program of the National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health. P.H. acknowledges financial support from National Science Foundation of China (81401465, 51573096). We acknowledge Maryland NanoCenter and its NispLab. NispLab is supported, in part, by the NSF in partnership with MRSEC Shared Experimental Facilities.Publisher
WileyJournal
Angewandte ChemieAdditional Links
http://onlinelibrary.wiley.com/doi/10.1002/anie.201608338/fullhttp://europepmc.org/articles/pmc5131874?pdf=render
ae974a485f413a2113503eed53cd6c53
10.1002/anie.201608338