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    Magneto-Plasmonic Janus Vesicles for Magnetic Field-Enhanced Photoacoustic and Magnetic Resonance Imaging of Tumors

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    Type
    Article
    Authors
    Liu, Yijing
    Yang, Xiangyu
    Huang, Zhiqi
    Huang, Peng
    Zhang, Yang
    Deng, Lin cc
    Wang, Zhantong
    Zhou, Zijian
    Liu, Yi cc
    Kalish, Heather
    Khashab, Niveen M. cc
    Chen, Xiaoyuan
    Nie, Zhihong cc
    KAUST Department
    Advanced Membranes and Porous Materials Research Center
    Chemical Science Program
    Physical Science and Engineering (PSE) Division
    Smart Hybrid Materials (SHMs) lab
    KAUST Grant Number
    CRG-2015
    Date
    2016-11-10
    Online Publication Date
    2016-11-09
    Print Publication Date
    2016-12-05
    Embargo End Date
    2017-11-10
    Permanent link to this record
    http://hdl.handle.net/10754/623166
    
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    Show full item record
    Abstract
    Magneto-plasmonic Janus vesicles (JVs) integrated with gold nanoparticles (AuNPs) and magnetic NPs (MNPs) were prepared asymmetrically in the membrane for in vivo cancer imaging. The hybrid JVs were produced by coassembling a mixture of hydrophobic MNPs, free amphiphilic block copolymers (BCPs), and AuNPs tethered with amphiphilic BCPs. Depending on the size and content of NPs, the JVs acquired spherical or hemispherical shapes. Among them, hemispherical JVs containing 50 nm AuNPs and 15 nm MNPs showed a strong absorption in the near-infrared (NIR) window and enhanced the transverse relaxation (T2) contrast effect, as a result of the ordering and dense packing of AuNPs and MNPs in the membrane. The magneto-plasmonic JVs were used as drug delivery vehicles, from which the release of a payload can be triggered by NIR light and the release rate can be modulated by a magnetic field. Moreover, the JVs were applied as imaging agents for in vivo bimodal photoacoustic (PA) and magnetic resonance (MR) imaging of tumors by intravenous injection. With an external magnetic field, the accumulation of the JVs in tumors was significantly increased, leading to a signal enhancement of approximately 2–3 times in the PA and MR imaging, compared with control groups without a magnetic field.
    Citation
    Liu Y, Yang X, Huang Z, Huang P, Zhang Y, et al. (2016) Magneto-Plasmonic Janus Vesicles for Magnetic Field-Enhanced Photoacoustic and Magnetic Resonance Imaging of Tumors. Angewandte Chemie International Edition 55: 15297–15300. Available: http://dx.doi.org/10.1002/anie.201608338.
    Sponsors
    Z.N. gratefully acknowledges the financial support of the National Science Foundation (grants: DMR-1255377, CHE-1505839) and 3M Non-tenured Faculty Award. N.M.K. and Z.N. further acknowledge support provided by a King Abdullah University of Science and Technology CRG-2015 grant. The work was also supported by the Intramural Research Program of the National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health. P.H. acknowledges financial support from National Science Foundation of China (81401465, 51573096). We acknowledge Maryland NanoCenter and its NispLab. NispLab is supported, in part, by the NSF in partnership with MRSEC Shared Experimental Facilities.
    Publisher
    Wiley
    Journal
    Angewandte Chemie
    DOI
    10.1002/anie.201608338
    10.1002/ange.201608338
    Additional Links
    http://onlinelibrary.wiley.com/doi/10.1002/anie.201608338/full
    http://europepmc.org/articles/pmc5131874?pdf=render
    ae974a485f413a2113503eed53cd6c53
    10.1002/anie.201608338
    Scopus Count
    Collections
    Articles; Advanced Membranes and Porous Materials Research Center; Physical Science and Engineering (PSE) Division; Controlled Release and Delivery Laboratory; Chemical Science Program

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