Folding Up of Gold Nanoparticle Strings into Plasmonic Vesicles for Enhanced Photoacoustic Imaging
Khashab, Niveen M.
KAUST DepartmentAdvanced Membranes and Porous Materials Research Center
Chemical Science Program
Physical Science and Engineering (PSE) Division
Smart Hybrid Materials (SHMs) lab
Online Publication Date2015-11-11
Print Publication Date2015-12-21
Embargo End Date2016-11-11
Permanent link to this recordhttp://hdl.handle.net/10754/623137
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AbstractThe stepwise self-assembly of hollow plasmonic vesicles with vesicular membranes containing strings of gold nanoparticles (NPs) is reported. The formation of chain vesicles can be controlled by tuning the density of the polymer ligands on the surface of the gold NPs. The strong absorption of the chain vesicles in the near-infrared (NIR) region leads to a much higher efficiency in photoacoustic (PA) imaging than for non-chain vesicles. The chain vesicles were further employed for the encapsulation of drugs and the NIR light triggered release of payloads. This work not only offers a new platform for controlling the hierarchical self-assembly of NPs, but also demonstrates that the physical properties of the materials can be tailored by controlling the spatial arrangement of NPs within assemblies to achieve a better performance in biomedical applications.
CitationLiu Y, He J, Yang K, Yi C, Liu Y, et al. (2015) Folding Up of Gold Nanoparticle Strings into Plasmonic Vesicles for Enhanced Photoacoustic Imaging. Angewandte Chemie International Edition 54: 15809–15812. Available: http://dx.doi.org/10.1002/anie.201508616.
SponsorsThis work was funded by a National Science Foundation (NSF) CAREER award (DMR-1255377), the ACS Petroleum Research Fund (PRF 53461-DNI7), a 3M non-tenured faculty award, and the Intramural Research Program of the National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health. We acknowledge support by the Maryland NanoCenter and its NispLab.