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dc.contributor.authorOke, Muse
dc.contributor.authorZaher, Manal
dc.contributor.authorHamdan, Samir
dc.date.accessioned2017-04-13T11:50:56Z
dc.date.available2017-04-13T11:50:56Z
dc.date.issued2014-07-14
dc.identifier.citationOke M, Zaher MS, Hamdan SM (2014) Division of Labor. Molecular Life Sciences: 1–5. Available: http://dx.doi.org/10.1007/978-1-4614-6436-5_134-1.
dc.identifier.doi10.1007/978-1-4614-6436-5_134-1
dc.identifier.doi10.1007/978-1-4614-1531-2_134
dc.identifier.urihttp://hdl.handle.net/10754/623132
dc.description.abstractThe first assignment of DNA polymerases at the eukaryotic replication fork was possible after the in vitro reconstitution of the simian virus 40 (SV40) replication system. In this system, DNA polymerase α (Pol α) provides both leading and lagging strands with RNA-DNA primers that are extended by DNA polymerase δ (Pol δ). Extrapolating the architecture of the replication fork from the SV40 model system to an actual eukaryotic cell has been challenged by the discovery of a third DNA polymerase in Saccharomyces cerevisiae, DNA polymerase ε (Pol ε). A division of labor has been proposed for the eukaryotic replication fork whereby Pol ε replicates the leading strand and Pol δ replicates the lagging strand. However, an alternative model of unequal division of labor in which Pol δ can still participate in leading-strand synthesis is plausible.
dc.publisherSpringer Nature
dc.relation.urlhttp://link.springer.com/chapter/10.1007/978-1-4614-6436-5_134-1
dc.titleDivision of Labor
dc.typeBook Chapter
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentDesert Agriculture Initiative
dc.contributor.departmentLaboratory of DNA Replication and Recombination
dc.identifier.journalMolecular Life Sciences
kaust.personOke, Muse
kaust.personZaher, Manal S.
kaust.personHamdan, Samir
dc.date.published-online2014-07-14
dc.date.published-print2014


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