Type
Book ChapterAuthors
Oke, MuseZaher, Manal

Hamdan, Samir

KAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionBioscience Program
Desert Agriculture Initiative
Laboratory of DNA Replication and Recombination
Date
2014-07-14Online Publication Date
2014-07-14Print Publication Date
2014Permanent link to this record
http://hdl.handle.net/10754/623132
Metadata
Show full item recordAbstract
The first assignment of DNA polymerases at the eukaryotic replication fork was possible after the in vitro reconstitution of the simian virus 40 (SV40) replication system. In this system, DNA polymerase α (Pol α) provides both leading and lagging strands with RNA-DNA primers that are extended by DNA polymerase δ (Pol δ). Extrapolating the architecture of the replication fork from the SV40 model system to an actual eukaryotic cell has been challenged by the discovery of a third DNA polymerase in Saccharomyces cerevisiae, DNA polymerase ε (Pol ε). A division of labor has been proposed for the eukaryotic replication fork whereby Pol ε replicates the leading strand and Pol δ replicates the lagging strand. However, an alternative model of unequal division of labor in which Pol δ can still participate in leading-strand synthesis is plausible.Citation
Oke M, Zaher MS, Hamdan SM (2014) Division of Labor. Molecular Life Sciences: 1–5. Available: http://dx.doi.org/10.1007/978-1-4614-6436-5_134-1.Publisher
Springer NatureJournal
Molecular Life SciencesAdditional Links
http://link.springer.com/chapter/10.1007/978-1-4614-6436-5_134-1ae974a485f413a2113503eed53cd6c53
10.1007/978-1-4614-6436-5_134-1