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    Type
    Book Chapter
    Authors
    Oke, Muse
    Zaher, Manal cc
    Hamdan, Samir cc
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Desert Agriculture Initiative
    Laboratory of DNA Replication and Recombination
    Date
    2014-07-14
    Online Publication Date
    2014-07-14
    Print Publication Date
    2014
    Permanent link to this record
    http://hdl.handle.net/10754/623132
    
    Metadata
    Show full item record
    Abstract
    The first assignment of DNA polymerases at the eukaryotic replication fork was possible after the in vitro reconstitution of the simian virus 40 (SV40) replication system. In this system, DNA polymerase α (Pol α) provides both leading and lagging strands with RNA-DNA primers that are extended by DNA polymerase δ (Pol δ). Extrapolating the architecture of the replication fork from the SV40 model system to an actual eukaryotic cell has been challenged by the discovery of a third DNA polymerase in Saccharomyces cerevisiae, DNA polymerase ε (Pol ε). A division of labor has been proposed for the eukaryotic replication fork whereby Pol ε replicates the leading strand and Pol δ replicates the lagging strand. However, an alternative model of unequal division of labor in which Pol δ can still participate in leading-strand synthesis is plausible.
    Citation
    Oke M, Zaher MS, Hamdan SM (2014) Division of Labor. Molecular Life Sciences: 1–5. Available: http://dx.doi.org/10.1007/978-1-4614-6436-5_134-1.
    Publisher
    Springer Nature
    Journal
    Molecular Life Sciences
    DOI
    10.1007/978-1-4614-6436-5_134-1
    10.1007/978-1-4614-1531-2_134
    Additional Links
    http://link.springer.com/chapter/10.1007/978-1-4614-6436-5_134-1
    ae974a485f413a2113503eed53cd6c53
    10.1007/978-1-4614-6436-5_134-1
    Scopus Count
    Collections
    Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program; Book Chapters; Desert Agriculture Initiative

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