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dc.contributor.authorKremb, Stephan Georg
dc.contributor.authorVoolstra, Christian R.
dc.date.accessioned2017-03-20T08:46:09Z
dc.date.available2017-03-20T08:46:09Z
dc.date.issued2017-03-15
dc.identifier.citationKremb S, Voolstra CR (2017) High-resolution phenotypic profiling of natural products-induced effects on the single-cell level. Scientific Reports 7: 44472. Available: http://dx.doi.org/10.1038/srep44472.
dc.identifier.issn2045-2322
dc.identifier.doi10.1038/srep44472
dc.identifier.urihttp://hdl.handle.net/10754/623036
dc.description.abstractNatural products (NPs) are highly evolved molecules making them a valuable resource for new therapeutics. Here we demonstrate the usefulness of broad-spectrum phenotypic profiling of NP-induced perturbations on single cells with imaging-based High-Content Screening to inform on physiology, mechanisms-of-actions, and multi-level toxicity. Our technology platform aims at broad applicability using a comprehensive marker panel with standardized settings streamlined towards an easy implementation in laboratories dedicated to natural products research.
dc.description.sponsorshipWe thank the Bioscience core lab for supporting cell culture work and providing the Cellomics ArrayScan HCS instrument. Research in this publication was supported by baseline funds to CRV from King Abdullah University of Science and Technology (KAUST).
dc.publisherSpringer Nature
dc.relation.urlhttp://www.nature.com/articles/srep44472
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleHigh-resolution phenotypic profiling of natural products-induced effects on the single-cell level
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentMarine Science Program
dc.contributor.departmentRed Sea Research Center (RSRC)
dc.identifier.journalScientific Reports
dc.eprint.versionPublisher's Version/PDF
kaust.personKremb, Stephan Georg
kaust.personVoolstra, Christian R.
refterms.dateFOA2018-06-14T04:41:39Z
dc.date.published-online2017-03-15
dc.date.published-print2017-12


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This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's license is described as This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/