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    Biocompatible 3D printed magnetic micro needles

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    BPEX-100599- Manuscript.pdf
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    Type
    Article
    Authors
    Kavaldzhiev, Mincho cc
    Perez, Jose E. cc
    Ivanov, Yurii P. cc
    Bertoncini, Andrea
    Liberale, Carlo cc
    Kosel, Jürgen cc
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    Electrical Engineering Program
    Date
    2017-02-21
    Permanent link to this record
    http://hdl.handle.net/10754/623023
    
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    Abstract
    Biocompatible functional materials play a significant role in drug delivery, tissue engineering and single cell analysis. We utilized 3D printing to produce high aspect ratio polymer resist microneedles on a silicon substrate and functionalized them by iron coating. Two-photon polymerization lithography has been used for printing cylindrical, pyramidal, and conical needles from a drop cast IP-DIP resist. Experiments with cells were conducted with cylindrical microneedles with 630 ± 15 nm in diameter with an aspect ratio of 1:10 and pitch of 12 μm. The needles have been arranged in square shaped arrays with various dimensions. The iron coating of the needles was 120 ± 15 nm thick and has isotropic magnetic behavior. The chemical composition and oxidation state were determined using energy electron loss spectroscopy, revealing a mixture of iron and Fe3O4 clusters. A biocompatibility assessment was performed through fluorescence microscopy using calcein/EthD-1 live/dead assay. The results show a very high biocompatibility of the iron coated needle arrays. This study provides a strategy to obtain electromagnetically functional microneedles that benefit from the flexibility in terms of geometry and shape of 3D printing. Potential applications are in areas like tissue engineering, single cell analysis or drug delivery.
    Citation
    Kavaldzhiev M, Perez JE, Ivanov Y, Bertoncini A, Liberale C, et al. (2017) Biocompatible 3D printed magnetic micro needles. Biomedical Physics & Engineering Express 3: 025005. Available: http://dx.doi.org/10.1088/2057-1976/aa5ccb.
    Publisher
    IOP Publishing
    Journal
    Biomedical Physics & Engineering Express
    DOI
    10.1088/2057-1976/aa5ccb
    Additional Links
    http://iopscience.iop.org/article/10.1088/2057-1976/aa5ccb/meta
    ae974a485f413a2113503eed53cd6c53
    10.1088/2057-1976/aa5ccb
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program; Electrical and Computer Engineering Program; Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division

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