Type
ArticleAuthors
Kavaldzhiev, Mincho
Perez, Jose E.

Ivanov, Yurii P.

Bertoncini, Andrea
Liberale, Carlo

Kosel, Jürgen

KAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionBioscience Program
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Electrical Engineering Program
Date
2017-02-21Permanent link to this record
http://hdl.handle.net/10754/623023
Metadata
Show full item recordAbstract
Biocompatible functional materials play a significant role in drug delivery, tissue engineering and single cell analysis. We utilized 3D printing to produce high aspect ratio polymer resist microneedles on a silicon substrate and functionalized them by iron coating. Two-photon polymerization lithography has been used for printing cylindrical, pyramidal, and conical needles from a drop cast IP-DIP resist. Experiments with cells were conducted with cylindrical microneedles with 630 ± 15 nm in diameter with an aspect ratio of 1:10 and pitch of 12 μm. The needles have been arranged in square shaped arrays with various dimensions. The iron coating of the needles was 120 ± 15 nm thick and has isotropic magnetic behavior. The chemical composition and oxidation state were determined using energy electron loss spectroscopy, revealing a mixture of iron and Fe3O4 clusters. A biocompatibility assessment was performed through fluorescence microscopy using calcein/EthD-1 live/dead assay. The results show a very high biocompatibility of the iron coated needle arrays. This study provides a strategy to obtain electromagnetically functional microneedles that benefit from the flexibility in terms of geometry and shape of 3D printing. Potential applications are in areas like tissue engineering, single cell analysis or drug delivery.Citation
Kavaldzhiev M, Perez JE, Ivanov Y, Bertoncini A, Liberale C, et al. (2017) Biocompatible 3D printed magnetic micro needles. Biomedical Physics & Engineering Express 3: 025005. Available: http://dx.doi.org/10.1088/2057-1976/aa5ccb.Publisher
IOP PublishingAdditional Links
http://iopscience.iop.org/article/10.1088/2057-1976/aa5ccb/metaae974a485f413a2113503eed53cd6c53
10.1088/2057-1976/aa5ccb