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dc.contributor.authorBajic, Vladan
dc.contributor.authorBajic, Vladimir B.
dc.contributor.authorZivkovic, Lada
dc.contributor.authorArendt, Thomas
dc.contributor.authorPerry, George
dc.contributor.authorSpremo-Potparevic, Biljana
dc.date.accessioned2017-03-15T07:15:27Z
dc.date.available2017-03-15T07:15:27Z
dc.date.issued2016
dc.identifier.citationBajic V, B. Bajic V, Zivkovic L, Arendt T, Perry G, et al. (2016) Late phase cell cycle proteins in Alzheimer’s disease: a possible target for therapy? Journal of Systems and Integrative Neuroscience 3. Available: http://dx.doi.org/10.15761/jsin.1000143.
dc.identifier.issn2059-9781
dc.identifier.doi10.15761/jsin.1000143
dc.identifier.urihttp://hdl.handle.net/10754/623004
dc.description.abstractAlzheimer’s disease (AD) is represented by neuronal loss and this loss is correlated to a constant state of neuronal instability induced by intrinsic and extrinsic factors. In this paper data is presented regarding the possible roles of late phase cell cycle proteins in normal and affected neurons with the goal that understanding the mechanisms involved in the regulation of these proteins may represent a novel strategy for AD treatment. The results demonstrate a relative differential pattern of expression of certain proteins (APC/C, Mad1 and Mad2, Bub R1, Bub1, CDK 11, cohesin subunit Rad 21 and astrin) in the AD brain versus age matched controls, and it is suggested that targeting these proteins might translate into potential treatments for AD. Although the data presented here is of some interest, the ability to translate such information into clinical applications is often a challenge.
dc.description.sponsorshipAuthor thanks the Fulbright Association , German DAAD Association and the Ministry of Education, Science and Technological Development of the Republic of Serbia for financial support (Project No: 173034).
dc.publisherOpen Access Text Pvt, Ltd.
dc.relation.urlhttp://oatext.com/Late-phase-cell-cycle-proteins-in-Alzheimers-disease-a-possible-target-for-therapy.php
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.subjectAlzheimer’s disease
dc.subjectneuronal instability
dc.titleLate phase cell cycle proteins in Alzheimer’s disease: a possible target for therapy?
dc.typeArticle
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentApplied Mathematics and Computational Science Program
dc.identifier.journalJournal of Systems and Integrative Neuroscience
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionDepartment of Radiobiology and Molecular Genetics, ‘’Vinca’’ Institute; PO Box 552, University of Belgrade, Belgrade, Serbia
dc.contributor.institutionDepartment of Endocrinology and Molecular Biology, ‘’Vinca’’ Institute; PO Box 552, Belgrade, Serbia
dc.contributor.institutionPaul-Flechsig-Institute for Brain Research, University of Leipzig, Medical Faculty, 04109, Leipzig, Germany
dc.contributor.institutionDepartment of Biology, The University of Texas at San Antonio, San Antonio, TX, 78249, USA
kaust.personBajic, Vladimir B.
refterms.dateFOA2018-06-13T13:22:18Z


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