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    Late phase cell cycle proteins in Alzheimer’s disease: a possible target for therapy?

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    JSIN-3-143.pdf
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    Type
    Article
    Authors
    Bajic, Vladan
    Bajic, Vladimir B. cc
    Zivkovic, Lada
    Arendt, Thomas
    Perry, George
    Spremo-Potparevic, Biljana
    KAUST Department
    Computational Bioscience Research Center (CBRC)
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    Applied Mathematics and Computational Science Program
    Date
    2016
    Permanent link to this record
    http://hdl.handle.net/10754/623004
    
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    Abstract
    Alzheimer’s disease (AD) is represented by neuronal loss and this loss is correlated to a constant state of neuronal instability induced by intrinsic and extrinsic factors. In this paper data is presented regarding the possible roles of late phase cell cycle proteins in normal and affected neurons with the goal that understanding the mechanisms involved in the regulation of these proteins may represent a novel strategy for AD treatment. The results demonstrate a relative differential pattern of expression of certain proteins (APC/C, Mad1 and Mad2, Bub R1, Bub1, CDK 11, cohesin subunit Rad 21 and astrin) in the AD brain versus age matched controls, and it is suggested that targeting these proteins might translate into potential treatments for AD. Although the data presented here is of some interest, the ability to translate such information into clinical applications is often a challenge.
    Citation
    Bajic V, B. Bajic V, Zivkovic L, Arendt T, Perry G, et al. (2016) Late phase cell cycle proteins in Alzheimer’s disease: a possible target for therapy? Journal of Systems and Integrative Neuroscience 3. Available: http://dx.doi.org/10.15761/jsin.1000143.
    Sponsors
    Author thanks the Fulbright Association , German DAAD Association and the Ministry of Education, Science and Technological Development of the Republic of Serbia for financial support (Project No: 173034).
    Publisher
    Open Access Text Pvt, Ltd.
    Journal
    Journal of Systems and Integrative Neuroscience
    DOI
    10.15761/jsin.1000143
    Additional Links
    http://oatext.com/Late-phase-cell-cycle-proteins-in-Alzheimers-disease-a-possible-target-for-therapy.php
    ae974a485f413a2113503eed53cd6c53
    10.15761/jsin.1000143
    Scopus Count
    Collections
    Articles; Applied Mathematics and Computational Science Program; Computational Bioscience Research Center (CBRC); Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division

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