Late phase cell cycle proteins in Alzheimer’s disease: a possible target for therapy?
B. Bajic, Vladimir
KAUST DepartmentComputational Bioscience Research Center (CBRC)
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Permanent link to this recordhttp://hdl.handle.net/10754/623004
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AbstractAlzheimer’s disease (AD) is represented by neuronal loss and this loss is correlated to a constant state of neuronal instability induced by intrinsic and extrinsic factors. In this paper data is presented regarding the possible roles of late phase cell cycle proteins in normal and affected neurons with the goal that understanding the mechanisms involved in the regulation of these proteins may represent a novel strategy for AD treatment. The results demonstrate a relative differential pattern of expression of certain proteins (APC/C, Mad1 and Mad2, Bub R1, Bub1, CDK 11, cohesin subunit Rad 21 and astrin) in the AD brain versus age matched controls, and it is suggested that targeting these proteins might translate into potential treatments for AD. Although the data presented here is of some interest, the ability to translate such information into clinical applications is often a challenge.
CitationBajic V, B. Bajic V, Zivkovic L, Arendt T, Perry G, et al. (2016) Late phase cell cycle proteins in Alzheimer’s disease: a possible target for therapy? Journal of Systems and Integrative Neuroscience 3. Available: http://dx.doi.org/10.15761/jsin.1000143.
SponsorsAuthor thanks the Fulbright Association , German DAAD Association and the Ministry of Education, Science and Technological Development of the Republic of Serbia for financial support (Project No: 173034).
PublisherOpen Access Text Pvt, Ltd.