Preparation and Biocompatible Surface Modification of Redox Altered Cerium Oxide Nanoparticle Promising for Nanobiology and Medicine
Type
ArticleAuthors
Nanda, Himansu Sekhar
KAUST Department
Physical Science and Engineering (PSE) DivisionWater Desalination and Reuse Research Center (WDRC)
Date
2016-11-03Permanent link to this record
http://hdl.handle.net/10754/622925
Metadata
Show full item recordAbstract
The biocompatible surface modification of metal oxide nanoparticles via surface functionalization technique has been used as an important tool in nanotechnology and medicine. In this report, we have prepared aqueous dispersible, trivalent metal ion (samarium)-doped cerium oxide nanoparticles (SmCNPs) as model redox altered CNPs of biological relevance. SmCNP surface modified with hydrophilic biocompatible (6-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-hexyl) triethoxysilane (MEEETES) were prepared using ammonia-induced ethylene glycol-assisted precipitation method and were characterized using a variety of complementary characterization techniques. The chemical interaction of functional moieties with the surface of doped nanoparticle was studied using powerful 13C cross polarization magic angle sample spinning nuclear magnetic resonance spectroscopy. The results demonstrated the production of the extremely small size MEEETES surface modified doped nanoparticles with significant reduction in aggregation compared to their unmodified state. Moreover, the functional moieties had strong chemical interaction with the surface of the doped nanoparticles. The biocompatible surface modification using MEEETES should also be extended to several other transition metal ion doped and co-doped CNPs for the production of aqueous dispersible redox altered CNPs that are promising for nanobiology and medicine.Citation
Nanda H (2016) Preparation and Biocompatible Surface Modification of Redox Altered Cerium Oxide Nanoparticle Promising for Nanobiology and Medicine. Bioengineering 3: 28. Available: http://dx.doi.org/10.3390/bioengineering3040028.Sponsors
The author would like to acknowledge the financial support from the King Abdullah University of Science and Technology (KAUST), Saudi Arabia.Publisher
MDPI AGJournal
BioengineeringAdditional Links
http://www.mdpi.com/2306-5354/3/4/28ae974a485f413a2113503eed53cd6c53
10.3390/bioengineering3040028