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    Preparation and Biocompatible Surface Modification of Redox Altered Cerium Oxide Nanoparticle Promising for Nanobiology and Medicine

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    bioengineering-03-00028.pdf
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    Type
    Article
    Authors
    Nanda, Himansu Sekhar cc
    KAUST Department
    Physical Science and Engineering (PSE) Division
    Water Desalination and Reuse Research Center (WDRC)
    Date
    2016-11-03
    Permanent link to this record
    http://hdl.handle.net/10754/622925
    
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    Abstract
    The biocompatible surface modification of metal oxide nanoparticles via surface functionalization technique has been used as an important tool in nanotechnology and medicine. In this report, we have prepared aqueous dispersible, trivalent metal ion (samarium)-doped cerium oxide nanoparticles (SmCNPs) as model redox altered CNPs of biological relevance. SmCNP surface modified with hydrophilic biocompatible (6-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-hexyl) triethoxysilane (MEEETES) were prepared using ammonia-induced ethylene glycol-assisted precipitation method and were characterized using a variety of complementary characterization techniques. The chemical interaction of functional moieties with the surface of doped nanoparticle was studied using powerful 13C cross polarization magic angle sample spinning nuclear magnetic resonance spectroscopy. The results demonstrated the production of the extremely small size MEEETES surface modified doped nanoparticles with significant reduction in aggregation compared to their unmodified state. Moreover, the functional moieties had strong chemical interaction with the surface of the doped nanoparticles. The biocompatible surface modification using MEEETES should also be extended to several other transition metal ion doped and co-doped CNPs for the production of aqueous dispersible redox altered CNPs that are promising for nanobiology and medicine.
    Citation
    Nanda H (2016) Preparation and Biocompatible Surface Modification of Redox Altered Cerium Oxide Nanoparticle Promising for Nanobiology and Medicine. Bioengineering 3: 28. Available: http://dx.doi.org/10.3390/bioengineering3040028.
    Sponsors
    The author would like to acknowledge the financial support from the King Abdullah University of Science and Technology (KAUST), Saudi Arabia.
    Publisher
    MDPI AG
    Journal
    Bioengineering
    DOI
    10.3390/bioengineering3040028
    Additional Links
    http://www.mdpi.com/2306-5354/3/4/28
    ae974a485f413a2113503eed53cd6c53
    10.3390/bioengineering3040028
    Scopus Count
    Collections
    Articles; Physical Science and Engineering (PSE) Division; Water Desalination and Reuse Research Center (WDRC)

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