Show simple item record

dc.contributor.authorAlsaiari, Shahad K.
dc.contributor.authorHammami, Mohamed Amen
dc.contributor.authorCroissant, Jonas G.
dc.contributor.authorOmar, Haneen
dc.contributor.authorNeelakanda, Pradeep
dc.contributor.authorYapici, Tahir
dc.contributor.authorPeinemann, Klaus-Viktor
dc.contributor.authorKhashab, Niveen M.
dc.date.accessioned2017-02-15T08:32:14Z
dc.date.available2017-02-15T08:32:14Z
dc.date.issued2017-01-25
dc.identifier.citationAlsaiari SK, Hammami MA, Croissant JG, Omar HW, Neelakanda P, et al. (2017) Colloidal Gold Nanoclusters Spiked Silica Fillers in Mixed Matrix Coatings: Simultaneous Detection and Inhibition of Healthcare-Associated Infections. Advanced Healthcare Materials: 1601135. Available: http://dx.doi.org/10.1002/adhm.201601135.
dc.identifier.issn2192-2640
dc.identifier.doi10.1002/adhm.201601135
dc.identifier.urihttp://hdl.handle.net/10754/622886
dc.description.abstractHealthcare-associated infections (HAIs) are the infections that patients get while receiving medical treatment in a medical facility with bacterial HAIs being the most common. Silver and gold nanoparticles (NPs) have been successfully employed as antibacterial motifs; however, NPs leaching in addition to poor dispersion and overall reproducibility are major hurdles to further product development. In this study, the authors design and fabricate a smart antibacterial mixed-matrix membrane coating comprising colloidal lysozyme-templated gold nanoclusters as nanofillers in poly(ethylene oxide)/poly(butylene terephthalate) amphiphilic polymer matrix. Mesoporous silica nanoparticles-lysozyme functionalized gold nanoclusters disperse homogenously within the polymer matrix with no phase separation and zero NPs leaching. This mixed-matrix coating can successfully sense and inhibit bacterial contamination via a controlled release mechanism that is only triggered by bacteria. The system is coated on a common radiographic dental imaging device (photostimulable phosphor plate) that is prone to oral bacteria contamination. Variation and eventually disappearance of the red fluorescence surface under UV light signals bacterial infection. Kanamycin, an antimicrobial agent, is controllably released to instantly inhibit bacterial growth. Interestingly, the quality of the images obtained with these coated surfaces is the same as uncoated surfaces and thus the safe application of such smart coatings can be expanded to include other medical devices without compromising their utility.
dc.description.sponsorshipS.K.A. and M.A.H. contributed equally to this work. The authors gratefully acknowledge Dr. Abdallah Abdallah from King Abdullah University of Science and Technology (KAUST) for providing E. coli. The authors also thank Dr. Asma'a A. Al-Ekrish from King Saud University and Dr. Alhasan Alsaiari from King Abdulaziz University College of Dentistry for providing and testing the dental imaging plates. The authors declare no competing financial interest.
dc.publisherWiley
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1002/adhm.201601135/full
dc.subjectControlled release
dc.subjectMesoporous Silica Nanoparticles
dc.subjectGold Nanoclusters
dc.subjectMixed Matrix Membranes
dc.subjectAntibacterial Surfaces
dc.titleColloidal Gold Nanoclusters Spiked Silica Fillers in Mixed Matrix Coatings: Simultaneous Detection and Inhibition of Healthcare-Associated Infections
dc.typeArticle
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Center
dc.contributor.departmentAnalytical Chemistry Core Lab
dc.contributor.departmentBioscience Program
dc.contributor.departmentChemical Engineering Program
dc.contributor.departmentChemical Science Program
dc.contributor.departmentEnvironmental Lab Inorganics
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.contributor.departmentSmart Hybrid Materials (SHMs) lab
dc.identifier.journalAdvanced Healthcare Materials
kaust.personAlsaiari, Shahad K.
kaust.personHammami, Mohamed Amen
kaust.personCroissant, Jonas G.
kaust.personOmar, Haneen
kaust.personNeelakanda, Pradeep
kaust.personYapici, Tahir
kaust.personPeinemann, Klaus-Viktor
kaust.personKhashab, Niveen M.
dc.date.published-online2017-01-25
dc.date.published-print2017-03


This item appears in the following Collection(s)

Show simple item record