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    Colloidal Gold Nanoclusters Spiked Silica Fillers in Mixed Matrix Coatings: Simultaneous Detection and Inhibition of Healthcare-Associated Infections

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    Type
    Article
    Authors
    Alsaiari, Shahad K. cc
    Hammami, Mohamed Amen cc
    Croissant, Jonas G.
    Omar, Haneen cc
    Neelakanda, Pradeep
    Yapici, Tahir
    Peinemann, Klaus-Viktor cc
    Khashab, Niveen M. cc
    KAUST Department
    Advanced Membranes and Porous Materials Research Center
    Analytical Chemistry Core Lab
    Bioscience Program
    Chemical Engineering Program
    Chemical Science Program
    Environmental Lab Inorganics
    Physical Science and Engineering (PSE) Division
    Smart Hybrid Materials (SHMs) lab
    Date
    2017-01-25
    Online Publication Date
    2017-01-25
    Print Publication Date
    2017-03
    Permanent link to this record
    http://hdl.handle.net/10754/622886
    
    Metadata
    Show full item record
    Abstract
    Healthcare-associated infections (HAIs) are the infections that patients get while receiving medical treatment in a medical facility with bacterial HAIs being the most common. Silver and gold nanoparticles (NPs) have been successfully employed as antibacterial motifs; however, NPs leaching in addition to poor dispersion and overall reproducibility are major hurdles to further product development. In this study, the authors design and fabricate a smart antibacterial mixed-matrix membrane coating comprising colloidal lysozyme-templated gold nanoclusters as nanofillers in poly(ethylene oxide)/poly(butylene terephthalate) amphiphilic polymer matrix. Mesoporous silica nanoparticles-lysozyme functionalized gold nanoclusters disperse homogenously within the polymer matrix with no phase separation and zero NPs leaching. This mixed-matrix coating can successfully sense and inhibit bacterial contamination via a controlled release mechanism that is only triggered by bacteria. The system is coated on a common radiographic dental imaging device (photostimulable phosphor plate) that is prone to oral bacteria contamination. Variation and eventually disappearance of the red fluorescence surface under UV light signals bacterial infection. Kanamycin, an antimicrobial agent, is controllably released to instantly inhibit bacterial growth. Interestingly, the quality of the images obtained with these coated surfaces is the same as uncoated surfaces and thus the safe application of such smart coatings can be expanded to include other medical devices without compromising their utility.
    Citation
    Alsaiari SK, Hammami MA, Croissant JG, Omar HW, Neelakanda P, et al. (2017) Colloidal Gold Nanoclusters Spiked Silica Fillers in Mixed Matrix Coatings: Simultaneous Detection and Inhibition of Healthcare-Associated Infections. Advanced Healthcare Materials: 1601135. Available: http://dx.doi.org/10.1002/adhm.201601135.
    Sponsors
    S.K.A. and M.A.H. contributed equally to this work. The authors gratefully acknowledge Dr. Abdallah Abdallah from King Abdullah University of Science and Technology (KAUST) for providing E. coli. The authors also thank Dr. Asma'a A. Al-Ekrish from King Saud University and Dr. Alhasan Alsaiari from King Abdulaziz University College of Dentistry for providing and testing the dental imaging plates. The authors declare no competing financial interest.
    Publisher
    Wiley
    Journal
    Advanced Healthcare Materials
    DOI
    10.1002/adhm.201601135
    Additional Links
    http://onlinelibrary.wiley.com/doi/10.1002/adhm.201601135/full
    ae974a485f413a2113503eed53cd6c53
    10.1002/adhm.201601135
    Scopus Count
    Collections
    Articles; Bioscience Program; Advanced Membranes and Porous Materials Research Center; Analytical Chemistry Core Lab; Physical Science and Engineering (PSE) Division; Controlled Release and Delivery Laboratory; Chemical Science Program; Chemical Engineering Program

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