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dc.contributor.authorBorrmann, Ruediger
dc.contributor.authorKnop, Nils
dc.contributor.authorRueping, Magnus
dc.date.accessioned2017-01-29T13:51:37Z
dc.date.available2017-01-29T13:51:37Z
dc.date.issued2016-12-15
dc.identifier.citationBorrmann R, Knop N, Rueping M (2016) Asymmetric Synthesis of Optically Active Spirocyclic Indoline Scaffolds through an Enantioselective Reduction of Indoles. Chemistry - A European Journal 23: 798–801. Available: http://dx.doi.org/10.1002/chem.201605450.
dc.identifier.issn0947-6539
dc.identifier.doi10.1002/chem.201605450
dc.identifier.urihttp://hdl.handle.net/10754/622768
dc.description.abstractAn enantioselective synthesis of spirocyclic indoline scaffolds was achieved by applying an asymmetric iridium-catalyzed hydrogenation of 3H-indoles. Low catalyst loadings and mild reaction conditions provide a broad range of differently substituted products with excellent yields and enantioselectivities. The developed methodology allows an efficient synthesis of this important spirocyclic structural motif, which is present in numerous biologically active molecules and privileged structures in medicinal chemistry.
dc.description.sponsorshipThe authors thank Solvias AG and Evonik Industries AG for donation of chiral ligands and metal salts.
dc.publisherWiley
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1002/chem.201605450/full
dc.subjectIndoles
dc.subjectPharmacophore
dc.subjectAsymmetric reduction
dc.subjectSpirocycles
dc.subjectIridium Catalysis
dc.titleAsymmetric Synthesis of Optically Active Spirocyclic Indoline Scaffolds through an Enantioselective Reduction of Indoles
dc.typeArticle
dc.contributor.departmentChemical Science Program
dc.contributor.departmentKAUST Catalysis Center (KCC)
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.identifier.journalChemistry - A European Journal
dc.contributor.institutionInstitute of Organic Chemistry; RWTH Aachen; Landoltweg 1 52074 Aachen Germany), Fax: (+49) 241-809-2665
kaust.personRueping, Magnus
dc.date.published-online2016-12-15
dc.date.published-print2017-01-18


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