Asymmetric Synthesis of Optically Active Spirocyclic Indoline Scaffolds through an Enantioselective Reduction of Indoles
Type
ArticleKAUST Department
Chemical Science ProgramKAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Date
2016-12-15Online Publication Date
2016-12-15Print Publication Date
2017-01-18Permanent link to this record
http://hdl.handle.net/10754/622768
Metadata
Show full item recordAbstract
An enantioselective synthesis of spirocyclic indoline scaffolds was achieved by applying an asymmetric iridium-catalyzed hydrogenation of 3H-indoles. Low catalyst loadings and mild reaction conditions provide a broad range of differently substituted products with excellent yields and enantioselectivities. The developed methodology allows an efficient synthesis of this important spirocyclic structural motif, which is present in numerous biologically active molecules and privileged structures in medicinal chemistry.Citation
Borrmann R, Knop N, Rueping M (2016) Asymmetric Synthesis of Optically Active Spirocyclic Indoline Scaffolds through an Enantioselective Reduction of Indoles. Chemistry - A European Journal 23: 798–801. Available: http://dx.doi.org/10.1002/chem.201605450.Sponsors
The authors thank Solvias AG and Evonik Industries AG for donation of chiral ligands and metal salts.Publisher
WileyJournal
Chemistry - A European JournalAdditional Links
http://onlinelibrary.wiley.com/doi/10.1002/chem.201605450/fullae974a485f413a2113503eed53cd6c53
10.1002/chem.201605450