Asymmetric Synthesis of Optically Active Spirocyclic Indoline Scaffolds through an Enantioselective Reduction of Indoles
KAUST DepartmentKAUST Catalysis Center (KCC)
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AbstractAn enantioselective synthesis of spirocyclic indoline scaffolds was achieved by applying an asymmetric iridium-catalyzed hydrogenation of 3H-indoles. Low catalyst loadings and mild reaction conditions provide a broad range of differently substituted products with excellent yields and enantioselectivities. The developed methodology allows an efficient synthesis of this important spirocyclic structural motif, which is present in numerous biologically active molecules and privileged structures in medicinal chemistry.
CitationBorrmann R, Knop N, Rueping M (2016) Asymmetric Synthesis of Optically Active Spirocyclic Indoline Scaffolds through an Enantioselective Reduction of Indoles. Chemistry - A European Journal 23: 798–801. Available: http://dx.doi.org/10.1002/chem.201605450.
SponsorsThe authors thank Solvias AG and Evonik Industries AG for donation of chiral ligands and metal salts.
JournalChemistry - A European Journal