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dc.contributor.authorLi, Mo
dc.contributor.authorBelmonte, Juan Carlos Izpisua
dc.date.accessioned2017-01-10T13:59:56Z
dc.date.available2017-01-10T13:59:56Z
dc.date.issued2017-01-03
dc.identifier.citationGround rules of the pluripotency gene regulatory network. 2017 Nat. Rev. Genet.
dc.identifier.issn1471-0064
dc.identifier.pmid28045100
dc.identifier.doi10.1038/nrg.2016.156
dc.identifier.urihttp://hdl.handle.net/10754/622673
dc.description.abstractPluripotency is a state that exists transiently in the early embryo and, remarkably, can be recapitulated in vitro by deriving embryonic stem cells or by reprogramming somatic cells to become induced pluripotent stem cells. The state of pluripotency, which is stabilized by an interconnected network of pluripotency-associated genes, integrates external signals and exerts control over the decision between self-renewal and differentiation at the transcriptional, post-transcriptional and epigenetic levels. Recent evidence of alternative pluripotency states indicates the regulatory flexibility of this network. Insights into the underlying principles of the pluripotency network may provide unprecedented opportunities for studying development and for regenerative medicine.
dc.description.sponsorshipThe authors apologize to the colleagues whose work is not covered in this article because of space constraints. The authors would like to thank D. O'Keefe and M. Schwarz for critical reading and generous help during the preparation of the manuscript. Work in the laboratory of J.C.I.B. is supported by the G. Harold and Leila Y. Mathers Charitable Foundation, The Leona M. and Harry B. Helmsley Charitable Trust (grant 2012-PG-MED002), the Moxie Foundation, Fundacion Dr. Pedro Guillen and the Universidad Católica San Antonio de Murcia (UCAM).
dc.language.isoen
dc.language.isoen
dc.publisherSpringer Nature
dc.relation.urlhttp://www.nature.com/nrg/journal/vaop/ncurrent/full/nrg.2016.156.html
dc.rightsArchived with thanks to Nature reviews. Genetics
dc.subjectpluripotent stem cells
dc.subjectGene Expression Regulation
dc.titleGround rules of the pluripotency gene regulatory network.
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.identifier.journalNature Reviews Genetics
dc.eprint.versionPost-print
dc.contributor.institutionSalk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
dc.contributor.institutionUniversidad Católica San Antonio de Murcia (UCAM) Campus de los Jerónimos, No. 135 Guadalupe 30107, Murcia, Spain.
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
kaust.personLi, Mo
refterms.dateFOA2017-07-03T00:00:00Z
dc.date.published-online2017-01-03
dc.date.published-print2017-03


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