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    Ground rules of the pluripotency gene regulatory network.

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    Belmonte_line_edit_accepted_1478880153_3.pdf
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    Description:
    Accepted Manuscript
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    Type
    Article
    Authors
    Li, Mo cc
    Belmonte, Juan Carlos Izpisua cc
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Date
    2017-01-03
    Online Publication Date
    2017-01-03
    Print Publication Date
    2017-03
    Permanent link to this record
    http://hdl.handle.net/10754/622673
    
    Metadata
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    Abstract
    Pluripotency is a state that exists transiently in the early embryo and, remarkably, can be recapitulated in vitro by deriving embryonic stem cells or by reprogramming somatic cells to become induced pluripotent stem cells. The state of pluripotency, which is stabilized by an interconnected network of pluripotency-associated genes, integrates external signals and exerts control over the decision between self-renewal and differentiation at the transcriptional, post-transcriptional and epigenetic levels. Recent evidence of alternative pluripotency states indicates the regulatory flexibility of this network. Insights into the underlying principles of the pluripotency network may provide unprecedented opportunities for studying development and for regenerative medicine.
    Citation
    Ground rules of the pluripotency gene regulatory network. 2017 Nat. Rev. Genet.
    Sponsors
    The authors apologize to the colleagues whose work is not covered in this article because of space constraints. The authors would like to thank D. O'Keefe and M. Schwarz for critical reading and generous help during the preparation of the manuscript. Work in the laboratory of J.C.I.B. is supported by the G. Harold and Leila Y. Mathers Charitable Foundation, The Leona M. and Harry B. Helmsley Charitable Trust (grant 2012-PG-MED002), the Moxie Foundation, Fundacion Dr. Pedro Guillen and the Universidad Católica San Antonio de Murcia (UCAM).
    Publisher
    Springer Nature
    Journal
    Nature Reviews Genetics
    DOI
    10.1038/nrg.2016.156
    PubMed ID
    28045100
    Additional Links
    http://www.nature.com/nrg/journal/vaop/ncurrent/full/nrg.2016.156.html
    ae974a485f413a2113503eed53cd6c53
    10.1038/nrg.2016.156
    Scopus Count
    Collections
    Articles; Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program

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