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AbstractPluripotency is a state that exists transiently in the early embryo and, remarkably, can be recapitulated in vitro by deriving embryonic stem cells or by reprogramming somatic cells to become induced pluripotent stem cells. The state of pluripotency, which is stabilized by an interconnected network of pluripotency-associated genes, integrates external signals and exerts control over the decision between self-renewal and differentiation at the transcriptional, post-transcriptional and epigenetic levels. Recent evidence of alternative pluripotency states indicates the regulatory flexibility of this network. Insights into the underlying principles of the pluripotency network may provide unprecedented opportunities for studying development and for regenerative medicine.
CitationGround rules of the pluripotency gene regulatory network. 2017 Nat. Rev. Genet.
SponsorsThe authors apologize to the colleagues whose work is not covered in this article because of space constraints. The authors would like to thank D. O'Keefe and M. Schwarz for critical reading and generous help during the preparation of the manuscript. Work in the laboratory of J.C.I.B. is supported by the G. Harold and Leila Y. Mathers Charitable Foundation, The Leona M. and Harry B. Helmsley Charitable Trust (grant 2012-PG-MED002), the Moxie Foundation, Fundacion Dr. Pedro Guillen and the Universidad Católica San Antonio de Murcia (UCAM).
JournalNature Reviews Genetics
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