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Type
ArticleAuthors
Li, Mo
Belmonte, Juan Carlos Izpisua

KAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionBioscience Program
Date
2017-01-03Online Publication Date
2017-01-03Print Publication Date
2017-03Permanent link to this record
http://hdl.handle.net/10754/622673
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Show full item recordAbstract
Pluripotency is a state that exists transiently in the early embryo and, remarkably, can be recapitulated in vitro by deriving embryonic stem cells or by reprogramming somatic cells to become induced pluripotent stem cells. The state of pluripotency, which is stabilized by an interconnected network of pluripotency-associated genes, integrates external signals and exerts control over the decision between self-renewal and differentiation at the transcriptional, post-transcriptional and epigenetic levels. Recent evidence of alternative pluripotency states indicates the regulatory flexibility of this network. Insights into the underlying principles of the pluripotency network may provide unprecedented opportunities for studying development and for regenerative medicine.Citation
Ground rules of the pluripotency gene regulatory network. 2017 Nat. Rev. Genet.Sponsors
The authors apologize to the colleagues whose work is not covered in this article because of space constraints. The authors would like to thank D. O'Keefe and M. Schwarz for critical reading and generous help during the preparation of the manuscript. Work in the laboratory of J.C.I.B. is supported by the G. Harold and Leila Y. Mathers Charitable Foundation, The Leona M. and Harry B. Helmsley Charitable Trust (grant 2012-PG-MED002), the Moxie Foundation, Fundacion Dr. Pedro Guillen and the Universidad Católica San Antonio de Murcia (UCAM).Publisher
Springer NatureJournal
Nature Reviews GeneticsPubMed ID
28045100ae974a485f413a2113503eed53cd6c53
10.1038/nrg.2016.156
Scopus Count
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