KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
Online Publication Date2017-01-03
Print Publication Date2017-03
Permanent link to this recordhttp://hdl.handle.net/10754/622673
MetadataShow full item record
AbstractPluripotency is a state that exists transiently in the early embryo and, remarkably, can be recapitulated in vitro by deriving embryonic stem cells or by reprogramming somatic cells to become induced pluripotent stem cells. The state of pluripotency, which is stabilized by an interconnected network of pluripotency-associated genes, integrates external signals and exerts control over the decision between self-renewal and differentiation at the transcriptional, post-transcriptional and epigenetic levels. Recent evidence of alternative pluripotency states indicates the regulatory flexibility of this network. Insights into the underlying principles of the pluripotency network may provide unprecedented opportunities for studying development and for regenerative medicine.
CitationGround rules of the pluripotency gene regulatory network. 2017 Nat. Rev. Genet.
SponsorsThe authors apologize to the colleagues whose work is not covered in this article because of space constraints. The authors would like to thank D. O'Keefe and M. Schwarz for critical reading and generous help during the preparation of the manuscript. Work in the laboratory of J.C.I.B. is supported by the G. Harold and Leila Y. Mathers Charitable Foundation, The Leona M. and Harry B. Helmsley Charitable Trust (grant 2012-PG-MED002), the Moxie Foundation, Fundacion Dr. Pedro Guillen and the Universidad Católica San Antonio de Murcia (UCAM).
JournalNature Reviews Genetics
- O-GlcNAc regulates pluripotency and reprogramming by directly acting on core components of the pluripotency network.
- Authors: Jang H, Kim TW, Yoon S, Choi SY, Kang TW, Kim SY, Kwon YW, Cho EJ, Youn HD
- Issue date: 2012 Jul 6
- Role of Oct4 in maintaining and regaining stem cell pluripotency.
- Authors: Shi G, Jin Y
- Issue date: 2010 Dec 14
- Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier to induced pluripotency.
- Authors: Pasque V, Radzisheuskaya A, Gillich A, Halley-Stott RP, Panamarova M, Zernicka-Goetz M, Surani MA, Silva JC
- Issue date: 2012 Dec 15
- Chromatin connections to pluripotency and cellular reprogramming.
- Authors: Orkin SH, Hochedlinger K
- Issue date: 2011 Jun 10
- Pluripotency, Differentiation, and Reprogramming: A Gene Expression Dynamics Model with Epigenetic Feedback Regulation.
- Authors: Miyamoto T, Furusawa C, Kaneko K
- Issue date: 2015 Aug