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dc.contributor.authorMarquet, P.
dc.contributor.authorRothenfusser, K.
dc.contributor.authorRappaz, B.
dc.contributor.authorDepeursinge, Christian
dc.contributor.authorJourdain, P.
dc.contributor.authorMagistretti, Pierre J.
dc.date.accessioned2017-01-02T13:45:00Z
dc.date.available2017-01-02T13:45:00Z
dc.date.issued2016-05-03
dc.identifier.citationMarquet P, Rothenfusser K, Rappaz B, Depeursinge C, Jourdain P, et al. (2016) Quantitative phase-digital holographic microscopy: a new imaging modality to identify original cellular biomarkers of diseases. Quantitative Phase Imaging II. Available: http://dx.doi.org/10.1117/12.2213454.
dc.identifier.doi10.1117/12.2213454
dc.identifier.urihttp://hdl.handle.net/10754/622625
dc.description.abstractQuantitative phase microscopy (QPM) has recently emerged as a powerful label-free technique in the field of living cell imaging allowing to non-invasively measure with a nanometric axial sensitivity cell structure and dynamics. Since the phase retardation of a light wave when transmitted through the observed cells, namely the quantitative phase signal (QPS), is sensitive to both cellular thickness and intracellular refractive index related to the cellular content, its accurate analysis allows to derive various cell parameters and monitor specific cell processes, which are very likely to identify new cell biomarkers. Specifically, quantitative phase-digital holographic microscopy (QP-DHM), thanks to its numerical flexibility facilitating parallelization and automation processes, represents an appealing imaging modality to both identify original cellular biomarkers of diseases as well to explore the underlying pathophysiological processes.
dc.description.sponsorshipThe work presented in this review is the result of a close collaboration between the Microvision and microdiagnosis group (SCI / STI / CHD group) of EPFL with Florian Charrière, Jonas Kühn, Etienne Shaffer, and Christian Depeursinge, the Laboratory of Neuroenergetics and Cellular Dynamics, Brain and Mind Institute of EPFL with Pierre Magistretti, Benjamin Rappaz, Pascal Jourdain, the Center for Psychiatric neuroscience, CHUV with Daniel Boss, Kaspar Rothenfusser and the company Lyncée Tec SA, Lausanne (http://www.lynceetec.com). We thank the Swiss National Science Foundation (SNSF) grants n° CR3213_132993 the National Center of competence in research Synapsy (http://www.nccr-synapsy.ch/) as well as the fondation de Préfargier
dc.publisherSPIE-Intl Soc Optical Eng
dc.relation.urlhttp://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=2520810
dc.rightsCopyright 2016 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
dc.subjectDigital holographic microscopy
dc.subjectquantitative phase microscopy
dc.subjectcell imaging
dc.subjectcell volume
dc.subjectcell membrane fluctuations
dc.subjectcell biomarkers
dc.subjecthigh-throughput screening
dc.subjectpsychiatry disorders
dc.titleQuantitative phase-digital holographic microscopy: a new imaging modality to identify original cellular biomarkers of diseases
dc.typeConference Paper
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.identifier.journalQuantitative Phase Imaging II
dc.conference.date2016-02-14 to 2016-02-17
dc.conference.name2nd Conference on Quantitative Phase Imaging, QPI 2016
dc.conference.locationSan Francisco, CA, USA
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionInstitut Universitaire en Santé Mentale de Québec, Department of Psychiatry and Neuroscience, Université Laval, Quebec, QC, G1J 2G3, Canada
dc.contributor.institutionCentre de Neurosciences Psychiatriques, Département de Psychiatrie DP-CHUV, Site de Cery, Prilly-Lausanne, 1008, Switzerland
dc.contributor.institutionBrain Mind Institute, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, 1015, Switzerland
dc.contributor.institutionBiomolecular Screening Facility (BSF) École Polytechnique Fédérale de Lausanne, Lausanne, CH-1015, Switzerland
kaust.personDepeursinge, Christian
kaust.personMagistretti, Pierre J.
refterms.dateFOA2018-06-14T04:35:01Z
dc.date.published-online2016-05-03
dc.date.published-print2016-05-02


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