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dc.contributor.authorGladkovskaya, Olga
dc.contributor.authorGun'Ko, Yuri K.
dc.contributor.authorO'Connor, Gerard M.
dc.contributor.authorGogvadze, Vladimir
dc.contributor.authorRochev, Yury
dc.date.accessioned2017-01-02T09:55:30Z
dc.date.available2017-01-02T09:55:30Z
dc.date.issued2016-09-13
dc.identifier.citationGladkovskaya O, Gun’ko YK, O’Connor GM, Gogvadze V, Rochev Y (2016) In one harness: the interplay of cellular responses and subsequent cell fate after quantum dot uptake. Nanomedicine 11: 2603–2615. Available: http://dx.doi.org/10.2217/nnm-2016-0068.
dc.identifier.issn1743-5889
dc.identifier.issn1748-6963
dc.identifier.doi10.2217/nnm-2016-0068
dc.identifier.urihttp://hdl.handle.net/10754/622560
dc.description.abstractRapid growth and expansion of engineered nanomaterials will occur when the technology can be used safely. Quantum dots have excellent prospects in clinical applications, but the issue of toxicity has not yet been resolved. To enable their medical implementation, the effect on, and mechanisms in, live cells should be clearly known and predicted. A massive amount of experimental data dedicated to nanotoxicity has been accumulated to-date, but it lacks a logical structure. The current challenge is to organize existing knowledge into lucid biological and mathematical models. In our review we aim to describe the interplay of various cell death mechanisms triggered by quantum dots as a consequence of particle parameters and experimental conditions.
dc.description.sponsorshipThis work was conducted under the framework of INSPIRE, the Irish Government's Programme for Research in Third Level Institutions Cycle 5, National Development Plan 2007-2013 with the assistance of the European Regional Development Fund, the Science Foundation Ireland (SFI 12/IA/1300 project) and the Ministry of Education and Science of the Russian Federation (grant no. 14.B25.31.0002) and the Russian Science Foundation, grant no. 15-15-00132. The part of this review 'ROS formation' and 'Apoptosis' was supported by the Russian Science Foundation (grant no. 14-15-00463 to V Gogvadze). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict viiith the subject matter or materials discussed in the manuscript apart from those disclosed.
dc.publisherFuture Medicine Ltd
dc.subjectapoptosis
dc.subjectnanotoxicity
dc.subjectnecrosis
dc.subjectquantum dots
dc.titleIn one harness: the interplay of cellular responses and subsequent cell fate after quantum dot uptake
dc.typeArticle
dc.contributor.departmentKAUST Catalysis Center (KCC)
dc.identifier.journalNanomedicine
dc.contributor.institutionSchool of Physics, National University of Ireland, Galway, Ireland
dc.contributor.institutionCÚRAM - Centre for Research in Medical Devices, Galway, Ireland
dc.contributor.institutionCRANN and School of Chemistry, Trinity College Dublin, Ireland
dc.contributor.institutionITMO University, Saint Petersburg, 197101, Russian Federation
dc.contributor.institutionDivision of Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, Stockholm, 171 77, Sweden
dc.contributor.institutionMV Lomonosov Moscow State University, Moscow, 119991, Russian Federation
dc.contributor.institutionInstitute of Theoretical and Experimental Biophysics, Pushchino, 142290, Russian Federation
dc.contributor.institutionSchool of Chemistry, National University of Ireland, Galway, Ireland
dc.contributor.institutionSechenov First Moscow State Medical University, Institute for Regenerative Medicine, Russian Federation
kaust.personGladkovskaya, Olga
dc.date.published-online2016-09-13
dc.date.published-print2016-10


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