In one harness: the interplay of cellular responses and subsequent cell fate after quantum dot uptake

Type
Article

Authors
Gladkovskaya, Olga
Gun'Ko, Yuri K.
O'Connor, Gerard M.
Gogvadze, Vladimir
Rochev, Yury

KAUST Department
KAUST Catalysis Center (KCC)

Online Publication Date
2016-09-13

Print Publication Date
2016-10

Date
2016-09-13

Abstract
Rapid growth and expansion of engineered nanomaterials will occur when the technology can be used safely. Quantum dots have excellent prospects in clinical applications, but the issue of toxicity has not yet been resolved. To enable their medical implementation, the effect on, and mechanisms in, live cells should be clearly known and predicted. A massive amount of experimental data dedicated to nanotoxicity has been accumulated to-date, but it lacks a logical structure. The current challenge is to organize existing knowledge into lucid biological and mathematical models. In our review we aim to describe the interplay of various cell death mechanisms triggered by quantum dots as a consequence of particle parameters and experimental conditions.

Citation
Gladkovskaya O, Gun’ko YK, O’Connor GM, Gogvadze V, Rochev Y (2016) In one harness: the interplay of cellular responses and subsequent cell fate after quantum dot uptake. Nanomedicine 11: 2603–2615. Available: http://dx.doi.org/10.2217/nnm-2016-0068.

Acknowledgements
This work was conducted under the framework of INSPIRE, the Irish Government's Programme for Research in Third Level Institutions Cycle 5, National Development Plan 2007-2013 with the assistance of the European Regional Development Fund, the Science Foundation Ireland (SFI 12/IA/1300 project) and the Ministry of Education and Science of the Russian Federation (grant no. 14.B25.31.0002) and the Russian Science Foundation, grant no. 15-15-00132. The part of this review 'ROS formation' and 'Apoptosis' was supported by the Russian Science Foundation (grant no. 14-15-00463 to V Gogvadze). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict viiith the subject matter or materials discussed in the manuscript apart from those disclosed.

Publisher
Future Medicine Ltd

Journal
Nanomedicine

DOI
10.2217/nnm-2016-0068

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