Development of a sensing system to detect C-telopeptide of type-I collagen
KAUST DepartmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Electrical Engineering Program
Online Publication Date2016-03-30
Print Publication Date2015-12
Permanent link to this recordhttp://hdl.handle.net/10754/622533
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AbstractThis research work describes a non-invasive and label-free immunosensing technique to detect the C-telopeptide of type-I collagen (CTX-1) by Electrochemical Impedance Spectroscopy (EIS). A planar interdigital capacitive sensor is used to evaluate the properties of the material under test. This sensor was fabricated on the basis of thin film micro-electromechanical system (MEMS) semiconductor device fabrication technology. EIS was used in conjunction with the sensor to detect collagen type-I in blood plasma. At the first stage, the Serum CrossLaps® ELISA was used to measure some known samples in order to obtain a standard curve. Streptavidin agarose was successfully immobilized on the sensing area of the sensor. After that the experiments were done with antibody solution and three known samples of CTX-1, zero concentration which was considered as control, 2.669 ng/ml and 0.798 ng/ml concentration. The results are encouraging for further investigation.
CitationAfsarimanesh N, Zia AI, Mukhopadhyay SC, Kruger M, Yu PL, et al. (2015) Development of a sensing system to detect C-telopeptide of type-I collagen. 2015 9th International Conference on Sensing Technology (ICST). Available: http://dx.doi.org/10.1109/ICSensT.2015.7438466.
Conference/Event name9th International Conference on Sensing Technology, ICST 2015