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    Surface modification of promising cerium oxide nanoparticles for nanomedicine applications

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    Type
    Article
    Authors
    Nanda, Himansu Sekhar cc
    KAUST Department
    Physical Science and Engineering (PSE) Division
    Water Desalination and Reuse Research Center (WDRC)
    Date
    2016
    Permanent link to this record
    http://hdl.handle.net/10754/622476
    
    Metadata
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    Abstract
    Cerium oxide nanoparticles (CNPs) or nanoceria have emerged as a potential nanomedicine for the treatment of several diseases such as cancer. CNPs have a natural tendency to aggregate or agglomerate in their bare state, which leads to sedimentation in a biological environment. Since the natural biological environment is essentially aqueous, nanoparticle surface modification using suitable biocompatible hydrophilic chemical moieties is highly desirable to create effective aqueous dispersions. In this report, (6-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-hexyl)triethoxysilane was used as a functional, biocompatible organosilane to modify the surface of CNPs to produce promising nanoparticles which open substantial therapeutic avenues. The surface modified nanoparticles were produced in situ via an ammonia-induced ethylene glycol-assisted precipitation method and were characterized using complimentary characterization techniques. The interaction between the functional moiety and the nanoparticle was studied using powerful cross polarization/magic angle sample spinning solid state nuclear magnetic resonance spectroscopy. The surface-modified nanoparticles were extremely small and demonstrated a significant improvement in aqueous dispersibility. Moreover, the existence of a strong ionic coordination between the functional moiety and the surface of the nanoparticle was realised, indicating that the surface modified nanoceria are stable and that the nanoparticles should demonstrate an enhanced circulation time in a biological environment. The surface modification approach should be promising for the production of CNPs for nanomedicine applications. © The Royal Society of Chemistry.
    Citation
    Nanda HS (2016) Surface modification of promising cerium oxide nanoparticles for nanomedicine applications. RSC Adv 6: 111889–111894. Available: http://dx.doi.org/10.1039/c6ra23046f.
    Sponsors
    The author would like to acknowledge the financial support from King Abdullah University of Science and Technology (KAUST), Saudi Arabia.
    Publisher
    Royal Society of Chemistry (RSC)
    Journal
    RSC Advances
    DOI
    10.1039/c6ra23046f
    Additional Links
    http://pubs.rsc.org/en/Content/ArticleLanding/2016/RA/C6RA23046F
    ae974a485f413a2113503eed53cd6c53
    10.1039/c6ra23046f
    Scopus Count
    Collections
    Articles; Physical Science and Engineering (PSE) Division; Water Desalination and Reuse Research Center (WDRC)

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