Type
ArticleAuthors
Han, WeijingChen, Shaohua
Yuan, Wei
Fan, Qihui

Tian, Jianxiang
Wang, Xiaochen
Chen, Longqing
Zhang, Xixiang

Wei, Weili
Liu, Ruchuan
Qu, Junle
Jiao, Yang
Austin, Robert H.
Liu, Liyu
KAUST Department
Imaging and Characterization Core LabNanofabrication Core Lab
Physical Science and Engineering (PSE) Division
Date
2016-09-23Online Publication Date
2016-09-23Print Publication Date
2016-10-04Permanent link to this record
http://hdl.handle.net/10754/622443
Metadata
Show full item recordAbstract
In this work, we constructed a Collagen I-Matrigel composite extracellular matrix (ECM). The composite ECM was used to determine the influence of the local collagen fiber orientation on the collective intravasation ability of tumor cells. We found that the local fiber alignment enhanced cell-ECM interactions. Specifically, metastatic MDA-MB-231 breast cancer cells followed the local fiber alignment direction during the intravasation into rigid Matrigel (∼10 mg/mL protein concentration).Citation
Han W, Chen S, Yuan W, Fan Q, Tian J, et al. (2016) Oriented collagen fibers direct tumor cell intravasation. Proceedings of the National Academy of Sciences 113: 11208–11213. Available: http://dx.doi.org/10.1073/pnas.1610347113.Sponsors
National Cancer Institute[U54CA143803]Natural Science Foundation of Beijing Municipality[7154221]
State Key Development Program Basic Research China[2013CB837200]
National Science Foundation China[11474345, 11274200]
ae974a485f413a2113503eed53cd6c53
10.1073/pnas.1610347113