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    Oriented collagen fibers direct tumor cell intravasation

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    Type
    Article
    Authors
    Han, Weijing
    Chen, Shaohua
    Yuan, Wei
    Fan, Qihui cc
    Tian, Jianxiang
    Wang, Xiaochen
    Chen, Longqing
    Zhang, Xixiang cc
    Wei, Weili
    Liu, Ruchuan
    Qu, Junle
    Jiao, Yang
    Austin, Robert H.
    Liu, Liyu
    KAUST Department
    Imaging and Characterization Core Lab
    Nanofabrication Core Lab
    Physical Science and Engineering (PSE) Division
    Date
    2016-09-23
    Online Publication Date
    2016-09-23
    Print Publication Date
    2016-10-04
    Permanent link to this record
    http://hdl.handle.net/10754/622443
    
    Metadata
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    Abstract
    In this work, we constructed a Collagen I-Matrigel composite extracellular matrix (ECM). The composite ECM was used to determine the influence of the local collagen fiber orientation on the collective intravasation ability of tumor cells. We found that the local fiber alignment enhanced cell-ECM interactions. Specifically, metastatic MDA-MB-231 breast cancer cells followed the local fiber alignment direction during the intravasation into rigid Matrigel (∼10 mg/mL protein concentration).
    Citation
    Han W, Chen S, Yuan W, Fan Q, Tian J, et al. (2016) Oriented collagen fibers direct tumor cell intravasation. Proceedings of the National Academy of Sciences 113: 11208–11213. Available: http://dx.doi.org/10.1073/pnas.1610347113.
    Sponsors
    National Cancer Institute[U54CA143803]
    Natural Science Foundation of Beijing Municipality[7154221]
    State Key Development Program Basic Research China[2013CB837200]
    National Science Foundation China[11474345, 11274200]
    Publisher
    Proceedings of the National Academy of Sciences
    Journal
    Proceedings of the National Academy of Sciences
    DOI
    10.1073/pnas.1610347113
    ae974a485f413a2113503eed53cd6c53
    10.1073/pnas.1610347113
    Scopus Count
    Collections
    Nanofabrication Core Lab; Articles; Imaging and Characterization Core Lab; Physical Science and Engineering (PSE) Division

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