Few molecule SERS detection using nanolens based plasmonic nanostructure: application to point mutation detection
Coluccio, Maria Laura
Di Fabrizio, Enzo M.
KAUST DepartmentPhysical Sciences and Engineering (PSE) Division
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AbstractAdvancements in nanotechnology fabrication techniques allow the possibility to design and fabricate a device with a minimum gap (<10 nm) between the composing nanostructures in order to obtain better control over the creation and spatial definition of plasmonic hot-spots. The present study is intended to show the fabrication of nanolens and their application to single/few molecules detection. Theoretical simulations were performed on different designs of real structures, including comparison of rough and smooth surfaces. Various molecules (rhodamine 6G, benzenethiol and BRCA1/BRCT peptides) were examined in this regard. Single molecule detection was possible for synthetic peptides, with a possible application in early detection of diseases. © The Royal Society of Chemistry.
CitationDas G, Alrasheed S, Coluccio ML, Gentile F, Nicastri A, et al. (2016) Few molecule SERS detection using nanolens based plasmonic nanostructure: application to point mutation detection. RSC Adv 6: 107916–107923. Available: http://dx.doi.org/10.1039/c6ra23301e.
PublisherRoyal Society of Chemistry (RSC)