Type
ArticleAuthors
Yi, YingButtner, Ulrich
Carreno, Armando Arpys Arevalo

Conchouso Gonzalez, David

Foulds, Ian G.
KAUST Department
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) DivisionElectrical Engineering Program
Date
2015-09-14Online Publication Date
2015-09-14Print Publication Date
2015-10-01Permanent link to this record
http://hdl.handle.net/10754/622371
Metadata
Show full item recordAbstract
This paper reports the design of a proof-of-concept drug delivery device that is actuated using the bubbles formed during electrolysis. The device uses a platinum (Pt) coated nickel (Ni) metal foam and a solid drug in reservoir (SDR) approach to improve the device's performance. This electrochemically-driven pump has many features that are unlike conventional drug delivery devices: it is capable of pumping periodically and being refilled automatically; it features drug release control; and it enables targeted delivery. Pt-coated metal foam is used as a catalytic reforming element, which reduces the period of each delivery cycle. Two methods were used for fabricating the Pt-coated metal: sputtering and electroplating. Of these two methods, the sputtered Pt-coated metal foam has a higher pumping rate; it also has a comparable recombination rate when compared to the electroplated Pt-coated metal foam. The only drawback of this catalytic reformer is that it consumes nickel scaffold. Considering long-term applications, the electroplated Pt metal foam was selected for drug delivery, where a controlled drug release rate of 2.2 μg ± 0.3 μg per actuation pulse was achieved using 4 mW of power.Citation
Yi Y, Buttner U, Carreno AAA, Conchouso D, Foulds IG (2015) A pulsed mode electrolytic drug delivery device. Journal of Micromechanics and Microengineering 25: 105011. Available: http://dx.doi.org/10.1088/0960-1317/25/10/105011.Publisher
IOP Publishingae974a485f413a2113503eed53cd6c53
10.1088/0960-1317/25/10/105011