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dc.contributor.authorDippenaar, Anzaan
dc.contributor.authorParsons, Sven David Charles
dc.contributor.authorSampson, Samantha Leigh
dc.contributor.authorVan Der Merwe, Ruben Gerhard
dc.contributor.authorDrewe, Julian Ashley
dc.contributor.authorAbdallah, Abdallah
dc.contributor.authorSiame, Kabengele Keith
dc.contributor.authorGey Van Pittius, Nicolaas Claudius
dc.contributor.authorVan Helden, Paul David
dc.contributor.authorPain, Arnab
dc.contributor.authorWarren, Robin Mark
dc.date.accessioned2017-01-02T09:08:27Z
dc.date.available2017-01-02T09:08:27Z
dc.date.issued2015-10-21
dc.identifier.citationDippenaar A, Parsons SDC, Sampson SL, van der Merwe RG, Drewe JA, et al. (2015) Whole genome sequence analysis of Mycobacterium suricattae. Tuberculosis 95: 682–688. Available: http://dx.doi.org/10.1016/j.tube.2015.10.001.
dc.identifier.issn1472-9792
dc.identifier.pmid26542221
dc.identifier.doi10.1016/j.tube.2015.10.001
dc.identifier.urihttp://hdl.handle.net/10754/622349
dc.description.abstractTuberculosis occurs in various mammalian hosts and is caused by a range of different lineages of the Mycobacterium tuberculosis complex (MTBC). A recently described member, Mycobacterium suricattae, causes tuberculosis in meerkats (Suricata suricatta) in Southern Africa and preliminary genetic analysis showed this organism to be closely related to an MTBC pathogen of rock hyraxes (Procavia capensis), the dassie bacillus. Here we make use of whole genome sequencing to describe the evolution of the genome of M. suricattae, including known and novel regions of difference, SNPs and IS6110 insertion sites. We used genome-wide phylogenetic analysis to show that M. suricattae clusters with the chimpanzee bacillus, previously isolated from a chimpanzee (Pan troglodytes) in West Africa. We propose an evolutionary scenario for the Mycobacterium africanum lineage 6 complex, showing the evolutionary relationship of M. africanum and chimpanzee bacillus, and the closely related members M. suricattae, dassie bacillus and Mycobacterium mungi.
dc.description.sponsorshipThis paper has relied on records of individual identities and/or life histories maintained by the Kalahari Meerkat Project, which has been supported by the European Research Council (Research Grant No. 294494 to T.H. Clutton-Brock since 1/7/2012) and the University of Zurich. This work was supported by the South African National Research Foundation (NRF), fund number 41744, South African Medical Research Council (MRC), Harry Crossley Foundation, Claude Leon Foundation, the Department of Biomedical Sciences, Stellenbosch University and King Abdullah University of Science and Technology (KAUST). S.L. Sampson is funded by the South African Research Chairs Initiative of the Department of Science and Technology and NRF of South Africa, award number UID 86539. Any opinion, finding and conclusion or recommendation expressed in this material is that of the author(s) and the NRF does not accept any liability in this regard.
dc.publisherElsevier BV
dc.subjectHigh-throughput nucleotide sequencing
dc.subjectMeerkat
dc.subjectMycobacterium suricattae
dc.subjectTuberculosis
dc.titleWhole genome sequence analysis of Mycobacterium suricattae
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentPathogen Genomics Laboratory
dc.identifier.journalTuberculosis
dc.contributor.institutionDST-NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa
dc.contributor.institutionRoyal Veterinary College, London, United Kingdom
kaust.personAbdallah, Abdallah
kaust.personPain, Arnab


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