Type
ArticleAuthors
Dippenaar, AnzaanParsons, Sven David Charles
Sampson, Samantha Leigh
Van Der Merwe, Ruben Gerhard
Drewe, Julian Ashley
Abdallah, Abdallah
Siame, Kabengele Keith
Gey Van Pittius, Nicolaas Claudius
Van Helden, Paul David
Pain, Arnab

Warren, Robin Mark
KAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionBioscience Core Lab
Bioscience Program
Pathogen Genomics Laboratory
Date
2015-10-21Online Publication Date
2015-10-21Print Publication Date
2015-12Permanent link to this record
http://hdl.handle.net/10754/622349
Metadata
Show full item recordAbstract
Tuberculosis occurs in various mammalian hosts and is caused by a range of different lineages of the Mycobacterium tuberculosis complex (MTBC). A recently described member, Mycobacterium suricattae, causes tuberculosis in meerkats (Suricata suricatta) in Southern Africa and preliminary genetic analysis showed this organism to be closely related to an MTBC pathogen of rock hyraxes (Procavia capensis), the dassie bacillus. Here we make use of whole genome sequencing to describe the evolution of the genome of M. suricattae, including known and novel regions of difference, SNPs and IS6110 insertion sites. We used genome-wide phylogenetic analysis to show that M. suricattae clusters with the chimpanzee bacillus, previously isolated from a chimpanzee (Pan troglodytes) in West Africa. We propose an evolutionary scenario for the Mycobacterium africanum lineage 6 complex, showing the evolutionary relationship of M. africanum and chimpanzee bacillus, and the closely related members M. suricattae, dassie bacillus and Mycobacterium mungi.Citation
Dippenaar A, Parsons SDC, Sampson SL, van der Merwe RG, Drewe JA, et al. (2015) Whole genome sequence analysis of Mycobacterium suricattae. Tuberculosis 95: 682–688. Available: http://dx.doi.org/10.1016/j.tube.2015.10.001.Sponsors
This paper has relied on records of individual identities and/or life histories maintained by the Kalahari Meerkat Project, which has been supported by the European Research Council (Research Grant No. 294494 to T.H. Clutton-Brock since 1/7/2012) and the University of Zurich. This work was supported by the South African National Research Foundation (NRF), fund number 41744, South African Medical Research Council (MRC), Harry Crossley Foundation, Claude Leon Foundation, the Department of Biomedical Sciences, Stellenbosch University and King Abdullah University of Science and Technology (KAUST). S.L. Sampson is funded by the South African Research Chairs Initiative of the Department of Science and Technology and NRF of South Africa, award number UID 86539. Any opinion, finding and conclusion or recommendation expressed in this material is that of the author(s) and the NRF does not accept any liability in this regard.Publisher
Elsevier BVJournal
TuberculosisPubMed ID
26542221ae974a485f413a2113503eed53cd6c53
10.1016/j.tube.2015.10.001
Scopus Count
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