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    Whole genome sequence analysis of Mycobacterium suricattae

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    Type
    Article
    Authors
    Dippenaar, Anzaan
    Parsons, Sven David Charles
    Sampson, Samantha Leigh
    Van Der Merwe, Ruben Gerhard
    Drewe, Julian Ashley
    Abdallah, Abdallah
    Siame, Kabengele Keith
    Gey Van Pittius, Nicolaas Claudius
    Van Helden, Paul David
    Pain, Arnab cc
    Warren, Robin Mark
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Core Lab
    Bioscience Program
    Pathogen Genomics Laboratory
    Date
    2015-10-21
    Online Publication Date
    2015-10-21
    Print Publication Date
    2015-12
    Permanent link to this record
    http://hdl.handle.net/10754/622349
    
    Metadata
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    Abstract
    Tuberculosis occurs in various mammalian hosts and is caused by a range of different lineages of the Mycobacterium tuberculosis complex (MTBC). A recently described member, Mycobacterium suricattae, causes tuberculosis in meerkats (Suricata suricatta) in Southern Africa and preliminary genetic analysis showed this organism to be closely related to an MTBC pathogen of rock hyraxes (Procavia capensis), the dassie bacillus. Here we make use of whole genome sequencing to describe the evolution of the genome of M. suricattae, including known and novel regions of difference, SNPs and IS6110 insertion sites. We used genome-wide phylogenetic analysis to show that M. suricattae clusters with the chimpanzee bacillus, previously isolated from a chimpanzee (Pan troglodytes) in West Africa. We propose an evolutionary scenario for the Mycobacterium africanum lineage 6 complex, showing the evolutionary relationship of M. africanum and chimpanzee bacillus, and the closely related members M. suricattae, dassie bacillus and Mycobacterium mungi.
    Citation
    Dippenaar A, Parsons SDC, Sampson SL, van der Merwe RG, Drewe JA, et al. (2015) Whole genome sequence analysis of Mycobacterium suricattae. Tuberculosis 95: 682–688. Available: http://dx.doi.org/10.1016/j.tube.2015.10.001.
    Sponsors
    This paper has relied on records of individual identities and/or life histories maintained by the Kalahari Meerkat Project, which has been supported by the European Research Council (Research Grant No. 294494 to T.H. Clutton-Brock since 1/7/2012) and the University of Zurich. This work was supported by the South African National Research Foundation (NRF), fund number 41744, South African Medical Research Council (MRC), Harry Crossley Foundation, Claude Leon Foundation, the Department of Biomedical Sciences, Stellenbosch University and King Abdullah University of Science and Technology (KAUST). S.L. Sampson is funded by the South African Research Chairs Initiative of the Department of Science and Technology and NRF of South Africa, award number UID 86539. Any opinion, finding and conclusion or recommendation expressed in this material is that of the author(s) and the NRF does not accept any liability in this regard.
    Publisher
    Elsevier BV
    Journal
    Tuberculosis
    DOI
    10.1016/j.tube.2015.10.001
    PubMed ID
    26542221
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.tube.2015.10.001
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program; Bioscience Core Lab

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