Parsons, Sven David Charles
Sampson, Samantha Leigh
Van Der Merwe, Ruben Gerhard
Drewe, Julian Ashley
Siame, Kabengele Keith
Gey Van Pittius, Nicolaas Claudius
Van Helden, Paul David
Warren, Robin Mark
KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
Pathogen Genomics Laboratory
Permanent link to this recordhttp://hdl.handle.net/10754/622349
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AbstractTuberculosis occurs in various mammalian hosts and is caused by a range of different lineages of the Mycobacterium tuberculosis complex (MTBC). A recently described member, Mycobacterium suricattae, causes tuberculosis in meerkats (Suricata suricatta) in Southern Africa and preliminary genetic analysis showed this organism to be closely related to an MTBC pathogen of rock hyraxes (Procavia capensis), the dassie bacillus. Here we make use of whole genome sequencing to describe the evolution of the genome of M. suricattae, including known and novel regions of difference, SNPs and IS6110 insertion sites. We used genome-wide phylogenetic analysis to show that M. suricattae clusters with the chimpanzee bacillus, previously isolated from a chimpanzee (Pan troglodytes) in West Africa. We propose an evolutionary scenario for the Mycobacterium africanum lineage 6 complex, showing the evolutionary relationship of M. africanum and chimpanzee bacillus, and the closely related members M. suricattae, dassie bacillus and Mycobacterium mungi.
CitationDippenaar A, Parsons SDC, Sampson SL, van der Merwe RG, Drewe JA, et al. (2015) Whole genome sequence analysis of Mycobacterium suricattae. Tuberculosis 95: 682–688. Available: http://dx.doi.org/10.1016/j.tube.2015.10.001.
SponsorsThis paper has relied on records of individual identities and/or life histories maintained by the Kalahari Meerkat Project, which has been supported by the European Research Council (Research Grant No. 294494 to T.H. Clutton-Brock since 1/7/2012) and the University of Zurich. This work was supported by the South African National Research Foundation (NRF), fund number 41744, South African Medical Research Council (MRC), Harry Crossley Foundation, Claude Leon Foundation, the Department of Biomedical Sciences, Stellenbosch University and King Abdullah University of Science and Technology (KAUST). S.L. Sampson is funded by the South African Research Chairs Initiative of the Department of Science and Technology and NRF of South Africa, award number UID 86539. Any opinion, finding and conclusion or recommendation expressed in this material is that of the author(s) and the NRF does not accept any liability in this regard.
- Novel cause of tuberculosis in meerkats, South Africa.
- Authors: Parsons SD, Drewe JA, Gey van Pittius NC, Warren RM, van Helden PD
- Issue date: 2013 Dec
- Animal-adapted members of the Mycobacterium tuberculosis complex endemic to the southern African subregion.
- Authors: Clarke C, Van Helden P, Miller M, Parsons S
- Issue date: 2016 Apr 26
- Novel Mycobacterium tuberculosis complex isolate from a wild chimpanzee.
- Authors: Coscolla M, Lewin A, Metzger S, Maetz-Rennsing K, Calvignac-Spencer S, Nitsche A, Dabrowski PW, Radonic A, Niemann S, Parkhill J, Couacy-Hymann E, Feldman J, Comas I, Boesch C, Gagneux S, Leendertz FH
- Issue date: 2013 Jun
- Development and evaluation of a diagnostic cytokine-release assay for Mycobacterium suricattae infection in meerkats (Suricata suricatta).
- Authors: Clarke C, Patterson SJ, Drewe JA, van Helden PD, Miller MA, Parsons SD
- Issue date: 2017 Jan 4
- Genomic interrogation of the dassie bacillus reveals it as a unique RD1 mutant within the Mycobacterium tuberculosis complex.
- Authors: Mostowy S, Cousins D, Behr MA
- Issue date: 2004 Jan