Self-assembly behavior of well-defined polymethylene-block-poly(ethylene glycol) copolymers in aqueous solution
KAUST DepartmentKAUST Catalysis Center (KCC)
Physical Sciences and Engineering (PSE) Division
Polymer Synthesis Laboratory
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AbstractA series of well-defined amphiphilic polymethylene-b-poly(ethylene glycol) (PM-b-PEG) diblock copolymers, with different hydrophobic chain length, were synthesized by combining Diels-Alder reaction with polyhomologation. The successful synthetic procedure was confirmed by size-exclusion chromatography (SEC) and 1H NMR spectroscopy. These block copolymers self-assembled into spherical micelles in aqueous solutions and exhibit low critical micelle concentration (CMC) of 2–4 mg/mL, as determined by fluorescence spectroscopy using pyrene as a probe. Measurements of the micelle hydrodynamic diameters, performed by dynamic light scattering (DLS), cryo-transmission electron microscopy (cryo-TEM) and atomic force microscopy (AFM), revealed a direct dependence of the micelle size from the polymethylene block length.
CitationAlkayal N, Zapsas G, Bilalis P, Hadjichristidis N (2016) Self-assembly behavior of well-defined polymethylene-block-poly(ethylene glycol) copolymers in aqueous solution. Polymer 107: 415–421. Available: http://dx.doi.org/10.1016/j.polymer.2016.09.074.
SponsorsResearch reported in this publication supported by King Abdullah University of Science and Technology. The assistance of Dr Rachid Sougrat, KAUST Advanced Nanofabrication Imaging and Characterization Core Laboratory, in cryo-TEM experiments is gratefully acknowledged.