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dc.contributor.authorYe, Min
dc.contributor.authorWen, Yuelu
dc.contributor.authorLi, Huifang
dc.contributor.authorFu, Yejuan
dc.contributor.authorWang, Qinghao
dc.date.accessioned2017-01-02T09:08:25Z
dc.date.available2017-01-02T09:08:25Z
dc.date.issued2016-10-01
dc.identifier.citationYe M, Wen Y, Li H, Fu Y, Wang Q (2016) Metal-free hydration of aromatic haloalkynes to α-halomethyl ketones. Tetrahedron Letters 57: 4983–4986. Available: http://dx.doi.org/10.1016/j.tetlet.2016.09.088.
dc.identifier.issn0040-4039
dc.identifier.doi10.1016/j.tetlet.2016.09.088
dc.identifier.urihttp://hdl.handle.net/10754/622311
dc.description.abstractA highly regioselective and efficient metal-free hydration of aromatic haloalkynes to alpha-halomethyl ketones using cheap tetrafluoroboric acid as catalyst is described. The protocol is conducted under convenient conditions and affords products in good to excellent yields, with broad substrate scope, including a variety of aromatic alkynyl chlorides, alkynyl bromides, and alkynyl iodides. (C) 2016 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipThe authors thank the NSFC (21202023) and the NSF of Jiangxi Provincial Education Department (GJJ151005 and GJJ14656) for financial support.
dc.publisherElsevier BV
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S0040403916312722
dc.subjectMetal-free
dc.subjectHydration
dc.subjectHaloalkyne
dc.subjectalpha-Halomethyl ketone
dc.subjectRegioselectivity
dc.titleMetal-free hydration of aromatic haloalkynes to α-halomethyl ketones
dc.typeArticle
dc.contributor.departmentLaboratory for Computational and Theoretical Chemistry of Advanced Materials
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Division
dc.identifier.journalTetrahedron Letters
dc.contributor.institutionKey Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou, Jiangxi, China
kaust.personLi, Huifang


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