Metal-free hydration of aromatic haloalkynes to α-halomethyl ketones
KAUST DepartmentLaboratory for Computational and Theoretical Chemistry of Advanced Materials
Physical Sciences and Engineering (PSE) Division
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AbstractA highly regioselective and efficient metal-free hydration of aromatic haloalkynes to alpha-halomethyl ketones using cheap tetrafluoroboric acid as catalyst is described. The protocol is conducted under convenient conditions and affords products in good to excellent yields, with broad substrate scope, including a variety of aromatic alkynyl chlorides, alkynyl bromides, and alkynyl iodides. (C) 2016 Elsevier Ltd. All rights reserved.
CitationYe M, Wen Y, Li H, Fu Y, Wang Q (2016) Metal-free hydration of aromatic haloalkynes to α-halomethyl ketones. Tetrahedron Letters 57: 4983–4986. Available: http://dx.doi.org/10.1016/j.tetlet.2016.09.088.
SponsorsThe authors thank the NSFC (21202023) and the NSF of Jiangxi Provincial Education Department (GJJ151005 and GJJ14656) for financial support.